Quantification of etheno-DNA adducts using liquid chromatography, on-line sample processing, and electrospray tandem mass spectrometry

Chemical Research in Toxicology

Volumn 13, Issue 12, 2000, Pages 1259-1264

  Doerge, Daniel R ^a   Churchwell, Mona I ^a   Fang, Jia Long ^a   Beland, Frederick A ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYADENOSINE DERIVATIVE; DEOXYCYTIDINE; DNA; URETHAN;

ANALYTIC METHOD; ARTICLE; CANCER; CHEMICAL STRUCTURE; DIET; DNA ADDUCT; DNA MODIFICATION; EXPERIMENTAL MOUSE; HYDROLYSIS; LIQUID CHROMATOGRAPHY; LIVER; MUTAGENICITY; PLACENTA; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DEOXYADENOSINES; DEOXYCYTIDINE; DNA ADDUCTS; DNA DAMAGE; FEMALE; HUMANS; LIVER; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED STRAINS; ONLINE SYSTEMS; PLACENTA; RATS; RATS, SPRAGUE-DAWLEY; URETHANE;

ANIMALIA; RODENTIA;

EID: 0034485925     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0001575     Document Type: Article

References (2)

1. 6-Ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells. Biochemistry 35, 11487-11492.
2. Nair, J., Barbin, A., Velic, I., and Bartsch, H. (1999) Etheno DNA-base adducts from endogenous reactive species. Mutat. Res. 424, 59-70.