Physiological hyperinsulinemia stimulates p70S6k phosphorylation in human skeletal muscle

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 12, 2000, Pages 4900-4904

  Hillier, T ^a   Long, W ^a   Jahn, L ^a   Wei, L ^a   Barrett, E J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; INSULIN; MESSENGER RNA; PROTEIN P70; RIBOSOME PROTEIN; S6 KINASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; MALE; MUSCLE BIOPSY; NORMAL HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE; WESTERN BLOTTING;

ADULT; BLOOD GLUCOSE; BLOTTING, WESTERN; FEMALE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

ANIMALIA;

EID: 0034485843     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.12.4900     Document Type: Article

References (42)

1. Regulation of protein synthesis by insulin
2. Regulation of protein synthesis in heart muscle. II. Effect of amino acid levels and insulin on ribosomal aggregation
3. Effect of insulin on protein synthesis in skeletal muscle of an isolated perfused preparation of rat hemicorpus
4. Role of insulin in the regulation of protein synthesis
5. Effect of starvation on initiation of protein synthesis in skeletal muscle and heart
6. Effect of insulin and plasma amino acid concentrations on leucine metabolism in man
7. Dose-response curves of effects of insulin on leucine kinetics in humans
8. Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man
9. Insulin-mediated reduction of whole body protein breakdown: Dose-response effects on leucine metabolism in postabsorptive man
10. Effect of physiologic hyperinsulmemia on skeletal muscle protein synthesis and breakdown in man
11. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms
12. Attenuated responses of muscle protein synthesis to fasting and insulin in adult female rats
13. Response of protein syunthesis in human skeletal muscle to insulin: An investigation with L-[2H5]phenylalanine
14. Effect of Insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo
15. Does insulin stimulate muscle protein synthesis in humans
16. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle
17. Growth hormone acutely stimulates muscle protein synthesis in normal humans
18. Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism
19. Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm
20. Phas/4e-Bps as regulators of mRNA translation and cell proliferation
21. Insulin stimulates protein synthesis in muscle by enhancing the association of eif-4e and eif-4g
22. Regulation of p70 S6 kinase by phosphorylation in vivo
23. Molecular mechanisms for the control of translation by insulin
24. Regulation of p70s6k/p85s6k and its role in the cell cycle
25. Glucose clamp technique, a method for quantifying insulin secretion and resistance
26. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
27. Amino acid availability regulates p70 S6 kinase and multiple translation factors
28. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
29. Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo
30. Insulin stimulation of growth in diabetic rats: Synthesis and degradation of ribosomes and total tissue protein in skeletal muscle and heart
31. Cap-independent translation of heat shock messenger RNAs
32. The insulin signaling pathway
33. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
34. Stimulation of PHAS-I phosphorylation by insulin and IGF-I: A potential mechanism for IGF-I's greater effect to stimulate skeletal muscle protein synthesis in vivo
35. An isotopic method for in vivo measurement of muscle protein synthesis and degradation
36. Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults
37. Failure of insulin infusion to stimulate fractional muscle protein synthesis in type I diabetic patients
38. Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age
39. Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats
40. Response of rat heart and skeletal muscle protein in vivo to insulin and amino acid infusion
41. Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle
42. Differential regulation of MAP kinase, p70(S6K), and Akt by contraction and insulin in rat skeletal muscle