Antisense IGF and antisense IGF-IR therapy of malignancy

Advances in Experimental Medicine and Biology

Volumn 465, Issue , 2000, Pages 265-272

  Wang, H ^a   Liu, Y ^a   Wei, L ^a   Guo, Y ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENTARY RNA; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

CANCER; CANCER IMMUNIZATION; CANCER INHIBITION; CANCER THERAPY; CELL GROWTH; CELL PROLIFERATION; DRUG RECEPTOR BINDING; DRUG TARGETING; GENE THERAPY; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; GENE THERAPY; GENETIC VECTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RECEPTOR, IGF TYPE 1; RECEPTOR, IGF TYPE 2; RNA, ANTISENSE;

EID: 0034484084     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (33)

1. The insulin-like growth factor I receptor: A key to tumor growth?
2. Cell cycle and growth control
3. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo
4. Growth factors and cytokines in bone cell metabolism
5. Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
6. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer
7. Immunogene therapy: Both in vitro and in vivo gene transfer approaches
8. Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus
9. Growth factors as transforming proteins
10. Rat C6 glial cells synthesize insulin-like growth factor I (IGF-I) and express IGF-I receptors and IGF-II/mannose 6-phosphate receptors
11. Antitumor effects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines
12. Molecular and cellular aspects of the insulin-like growth factor I receptor
13. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor
14. Bone growth factors
15. Suppression of basic fibroblast growth factor expression by antisense oligodeoxynucleotides inhibits the growth of transformed human astrocytes
16. Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells
17. Decrease of proliferation rate and induction of differentiation by a MYCN antisense DNA oligomer in a human neuroblastoma cell line
18. Metallothionein-human GH fusion genes stimulate growth of mice
19. Type I IGF receptor in human breast diseases
20. Plasma insulin-like growth factor-(IGF concentrations in human breast cancer
21. The role of the insulin-like growth factor I receptor in transformation and apoptosis
22. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor
23. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-I (IGF-I) receptor are nontumorigenic and induce regression of wild-type tumors
24. Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells
25. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity
26. Insulin-like growth factors and their binding proteins
27. Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I
28. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA
29. Gene therapy of murine teratocarcinoma: Separate functions for insulin-like growth factors I and II in immunogenicity and differentiation
30. Immunotherapy of tumors expressing IGF-I
31. Presence of MHC-1 and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA
32. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
33. Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines