Rational design of platinum chemotherapeutic drugs: Hydrophobicity increases cytotoxicity

Anticancer Research

Volumn 20, Issue 6 B, 2000, Pages 4435-4439

  Moeller, N ^a   Kangarloo, B S ^a   Puscasu, I ^a   Mock, C ^a   Krebs, B ^a   Wolff, J E A ^a  

^a Pediatrics   (Canada)

Author keywords

Cisplatin; Cytotoxicity; Drug design; Glioma; Mesomeric effect

Indexed keywords

CISPLATIN; ETHYLPLATINUM; HEXAPLATINUM; NITROPLATINUM; OXIMPLATINUM; PHENANTHROPLATINUM; PHENYLPLATINUM; PLATINUM; PLATINUM DERIVATIVE; PYRIDYLPLATINUM; SULFIDPLATINUM; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CANCER CELL; CANCER CHEMOTHERAPY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EXPOSURE; GLIOBLASTOMA; HUMAN; HUMAN CELL; HYDROPHOBICITY; MEMBRANE PERMEABILITY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR WEIGHT; PLATINUM COMPOUNDS; SOLUBILITY; TUMOR CELLS, CULTURED;

EID: 0034479250     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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