Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of arabinofu-ranosyl cytosine in a myeloid leukemic cell-line

Advances in Experimental Medicine and Biology

Volumn 486, Issue , 2000, Pages 311-317

  Verschuur, A C ^a   Van Gennip, A H ^a   Leen, R ^a   Voute P A ^a   Van Kuilenburg, A B P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4,5 DIHYDROXY 3 HYDROXYMETHYL 2 CYCLOPENTEN 1 YL)CYTOSINE; CYTARABINE; DEOXYRIBONUCLEOTIDE; DNA;

CELL STRAIN HL 60; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; MYELOID LEUKEMIA; PHOSPHORYLATION; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CARBON-NITROGEN LIGASES; CYTARABINE; CYTIDINE; CYTIDINE DIPHOSPHATE; CYTIDINE MONOPHOSPHATE; DEOXYCYTOSINE NUCLEOTIDES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; PHOSPHORYLATION;

EID: 0034474153     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (12)

1. Antitumor activity and biochemical effects of cyclopentenylcytosine in mice
2. Induction of differentiation in the human promyelocytic leukemia cell-line HL-60 by the cyclopentenyl analogue of cytidine
3. Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts
4. In vitro inhibition of cytidine triphosphate synthetase in paediatric acute lymphocytic leukaemia
5. Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase activity in peaediatric acute non-lymphocytic leukemia: A promising target for chemotherapy
6. Correlation of cytotoxicity with incorporation of ara-C into DNA
7. Regulation of 1-β-D Arabinofuranosylcytosine 5-triphosphate accumulation in human leukemia cells by deoxycytidine 5-triphosphate
8. Effects of 1-beta-D-arabinofuranosylcytosine incorporation on elongation of specific DNA sequences by DNA polymerase beta
9. Transport and metabolism of deoxycytidine and 1-β-D arabinofuranosylcytosine into cultured novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis
10. Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-β-D-arabinofuranosylcytosine by cyclopentenyl cytosine
11. Pyrimidine nucleoside monophosphate kinase from human leukemic blast cells
12. Phase I clinical trial of continuous infusion cyclopentenyl cytosine