Cyclopentenyl cytosine induces apoptosis and secondary necrosis in a T-lymphoblastic leukemic cell-line

Advances in Experimental Medicine and Biology

Volumn 486, Issue , 2000, Pages 319-325

  Verschuur, A C ^a   Van Gennip, A H ^a   Brinkman, J ^a   Voute P A ^a   Van Kuilenburg, A B P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4,5 DIHYDROXY 3 HYDROXYMETHYL 2 CYCLOPENTEN 1 YL)CYTOSINE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROPIDIUM IODIDE;

APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; PRIORITY JOURNAL; T LYMPHOBLAST;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBON-NITROGEN LIGASES; CASPASES; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; CYTIDINE; ENZYME INHIBITORS; HUMANS; LEUKEMIA, T-CELL, ACUTE; TIME FACTORS;

EID: 0034472411     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (8)

1. Antitumor activity and biochemical effects of cyclopentenylcytosine in mice
2. Induction of differentiation in the human promyelocytic leukemia cell-line HL-60 by the cyclopentenyl analogue of cytidine
3. Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts
4. In vitro inhibition of cytidine triphosphate synthetase in paediatric acute lymphocytic leukaemia
5. Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase activity in peaediatric acute non-lymphocytic leukemia: A promising target for chemotherapy
6. Annexin V for flow cytometric detection of phosphateidylserine expression on B cells undergoing apoptosis
7. Two pathways of apoptosis induced with all-trans retinoic acid and etoposide in the myeloid cell line P39
8. Phase I clinical trial of continuous infusion cyclopentenyl cytosine