Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist

Acta Physiologica Scandinavica

Volumn 170, Issue 3, 2000, Pages 211-216

  Dwyer, D ^a   Browning, J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

5HT1A; Adaptation; Central fatigue; Exercise; Receptor; Serotonin; Training

Indexed keywords

SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ADAPTATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DRUG RECEPTOR BINDING; ENDURANCE; FATIGUE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; EXERCISE TEST; FATIGUE; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; TIME FACTORS;

EID: 0034470166     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2000.00774.x     Document Type: Article

References (31)

1. Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines
2. Antagonism of reserpine-induced suppression of spontaneous motor activity by stimulation of 5-HT1A receptors in rats
3. Different serotonin receptors mediate blood pressure, heart rate, plasma catecholamine and prolactin responses to m-chlorophenylpiperazine in conscious rats
4. Effect of increased brain serotonergic activity on endurance performance in the rat
5. Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue
6. Serotonergic agonists and antagonists affect endurance performance in the rat
7. Serotonin induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class
8. Changes in plasma concentrations of aromatic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue
9. Effect of sustained exercise on plasma amino acid concentrations and on 5-hydroxytryptamine metabolism in six different brain regions in the rat
10. Decreased neuroendocrine response to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners
11. Influence of physical exercise on 5-HT1A receptor and anxiety-related behaviours
12. Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat
13. Amphetamine and alpha-methyl-, p.-tyrosine affect the exercise-induced imbalance between the availability of tryptophan and synthesis of serotonin in the brain of the rat
14. Possible mechanisms of central nervous system fatigue during exercise
15. Physical exercise as a novel antidepressant agent - Possible role of serotonin receptor subtypes
16. Brain monoamine metabolism is altered in rats following spontaneous, long distance running
17. Effect of tryptophan and of glucose on exercise capacity of horses
18. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice
19. Peripheral factors as limitations to exercise capacity
20. 5-HT and motor control: A hypothesis
21. Evidence for down regulation of hypothalamic 5-hydroxytryptamine receptor function in endurance-trained athletes
22. 5-HT1A receptor hypersensitivity in migrane is suggested by the m-chlorophenylpiperazine test
23. Tolerance to the serotonin 5-HT1 agonist RU 24969 and effects on dopaminergic behaviour
24. 5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice
25. Effects of moderate and intensive training on functional activity of central 5-HT 1B receptors in the rat substantia nigra
26. Development of selective tolerance to the serotonin behavioural syndrome and suppression of locomotor activity, after repeated administration of either 5-MeODMT or mCPP
27. Increased serotonin levels in physically trained men. Physical exercise: Evidence for differential consequences of tryptophan on 5-HT synthesis and metabolism in central serotonergic cell bodies and terminals
28. Serotonin agonists reduce dopamine synthesis in the striatum only when the impuse flow of nigro stiatal neurons is intact
29. Long term administration of m-chlorophenylpiperazine (m-CPP) to rats induces changes in serotonin receptor binding, dopamine levels and locomotor activity without altering prolactin and corticosterone secretion
30. The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1a-like receptors
31. Evidence fox a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: Administration of paroxetine, a 5-HT re-uptake inbibitor, reduces the capacity to perform prolonged exercise