Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system

Journal of Chemical Neuroanatomy

Volumn 20, Issue 3-4, 2000, Pages 245-252

  Braak, Heiko ^a   Tredici, Kelly Del ^a   Gai, Wei Ping ^b   Braak, Eva ^a  

^a GOETHE UNIVERSITY   (Germany)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Parkinson's disease; Presynaptic boutons; Selective vulnerability; Synuclein family

Indexed keywords

ALPHA SYNUCLEIN; ANTIBODY;

AGED; ARTICLE; BRAIN MAPPING; BRAIN REGION; CELL INCLUSION; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LEWY BODY; MALE; MYELINATED NERVE; PARKINSON DISEASE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; ANTIBODIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOCORTEX; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PRESYNAPTIC TERMINALS; SYNUCLEINS; THALAMUS;

EID: 0034469821     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-0618(00)00101-0     Document Type: Article

References (43)

1. Immunoelectronmicroscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
2. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
3. Synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease β-amyloid plaque cores
4. Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections
5. Silver staining method for demonstrating Lewy bodies in Parkinson's disease and argyrophilic oligodendrocytes in multiple system atrophy
6. Neuropathological hallmarks of Alzheimer's and Parkinson's diseases
7. Parkinson's disease: Affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system
8. Alzheimer's plaques and tangles: A controlled and enhanced silver staining method
9. The synucleins: A familiy of proteins involved in synaptic function, plasticity, neurodegeneration and disease
10. Non-Aβ component of Alzheimer's disease amyloid (NAC) revisited. NAC and α-synuclein are not associated with Aβ amyloid
11. Stabilization of α-synuclein secondary structure upon binding to synthetic membranes
12. Neuropathology of synuclein aggregates: New insights into mechanisms of neurodegenerative diseases
13. Silver staining of Alzheimer's neurofibrillary changes by means of physical development
14. Alpha-synuclein immunoisolation of glial inclusions from multiple system atrophy brain tissue reveals multiprotein components
15. Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
16. Filamentous nerve cell inclusions in neurodegenerative diseases: Tauopathies and α-synucleinopathies
17. Alpha-synuclein in Lewy body disease and Alzheimer's disease
18. Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
19. Parkinsonism: Onset, progression, and mortality
20. Editorial on consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
21. Silver labeling of Alzheimer neurofibrillary changes and brain β-amyloid
22. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity
23. The synaptic protein NACP is abnormally expressed during the progression of Alzheimer's disease
24. Identification of two distinct synucleins from human brain
25. Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
26. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
27. The synuclein family
28. Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
29. Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
30. Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease
31. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
32. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
33. Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique
34. Polyethylene glycol embedding: A technique compatible with immunocytochemistry, enzyme histochemistry, histofluorescence and intracellular staining
35. Synuclein in Lewy bodies
36. Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
37. Abnormal distribution of the non-Aß component of Alzheimer's disease amyloid precursor/α-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment
38. Aggregation of neurofilament and α-synuclein proteins in Lewy bodies-implications for the pathogenesis of Parkinson-disease and Lewy body dementia
39. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer's disease
40. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease
41. Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy