Efficacy of vaccines containing rhoptry-associated proteins RAP1 and RAP2 of Plasmodium falciparum in Saimiri boliviensis monkeys

American Journal of Tropical Medicine and Hygiene

Volumn 62, Issue 4, 2000, Pages 466-479

  Collins, W E ^a   Walduck, A ^a   Sullivan, J S ^a   Andrews, K ^a   Stowers, A ^a   Morris, C L ^a   Jennings, V ^a   Yang, C ^a   Kendall, J ^a   Lin, Q ^a   Martin, L B ^a   Diggs, C ^a   Saul, A ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRL 1005 ADJUVANT; FREUND ADJUVANT; IMMUNOLOGICAL ADJUVANT; MALARIA VACCINE; MONTANIDE ISA720 ADJUVANT; PROTOZOAL PROTEIN; RHOPTRY ASSOCIATED PROTEIN 1; RHOPTRY ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; FEMALE; IMMUNIZATION; MALARIA CONTROL; MALARIA FALCIPARUM; MALE; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM;

ANIMALIA; PLASMODIUM FALCIPARUM; PROTOZOA; SAIMIRI BOLIVIENSIS;

EID: 0034469316     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2000.62.466     Document Type: Article

References (38)

1. An antigen complex in the rhoptries of Plasmodium falciparum
2. Inhibition of P. falciparum growth in human erythrocytes by monoclonal antibodies
3. Proteins responsible for a punctate fluorescence pattern in Plasmodium falciparum merozoites
4. A rhoptry antigen of Plasmodium falciparum contains conserved and variable epitopes recognized by inhibitory monoclonal antibodies
5. Identification and characterization of proteins associated with the rhoptry organelles of Plasmodium falciparum merozoites
6. Inhibitory monoclonal antibodies recognise epitopes adjacent to a proteolytic cleavage site on the RAP-1 protein of Plasmodium falciparum
7. Analysis of inhibitory epitopes in the Plasmodium falciparum rhoptry protein RAP-1 including identification of a second inhibitory epitope
8. Immunization with a Plasmodium falciparum merozoite surface antigen induces a partial immunity in monkeys
9. A rhoptry antigen of Plasmodium falciparum is protective in Saimiri monkeys
10. Genetic and structural relationships between components of a protective rhoptry antigen complex from Plasmodium falciparum
11. The 42-kilodalton rhoptry-associated protein of Plasmodium falciparum
12. Characterisation and sequence of a protective rhoptry antigen from Plasmodium falciparum
13. Immunogenicity of recombinant Plasmodium falciparum rhoptry associated proteins 1 and 2
14. Preparative scale purification of recombinant proteins to clinical grade by isotachophoresis
15. Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2
16. The sequence of the p82 rhoptry protein is highly conserved between two Plasmodium falciparum isolates
17. Limited RAP-1 sequence diversity in field isolates of Plasmodium falciparum
18. Phase 1 trial in humans of an oil-based adjuvant SEPPIC MONTANIDE ISA 720
19. Increasing the immunogenicity of a trivalent influenza virus vaccine with adjuvant-active nonionic block copolymers for potential use in the elderly
20. Development of an adjuvant-active nonionic block copolymer for use in oil-free subunit vaccine formulations
21. Resistance of ten Thai isolates of Plasmodium falciparum to chloroquine and pyrimethamine by in vitro tests
22. Plasmodium falciparum strains from Papua New Guinea: Culture characteristics and drug sensitivity
23. Enumeration of parasite in blood of malarial patients
24. Purification of mature schizonts of Plasmodium falciparum on colloidal silica gradients
25. Immunization of owl monkeys with ring-infected erythrocyte surface antigen of Plasmodium falciparum
26. Immunization of owl monkeys with a combination of Plasmodium falciparum asexual blood-stage synthetic peptide antigens
27. Immunogenicity and efficacy trials in Aotus nancymai monkeys with model compounds representing parts of a 75 kDa merozoite surface antigen
28. Selection of Aotus monkey models for testing Plasmodium falciparum blood-stage vaccines
29. Protective immunization with invariant peptides of the Plasmodium fatciparum antigen MSA2
30. A peptide derived from a B cell epitope of Plasmodium falciparum rhoptry associated protein 2 specifically raises antibodies to rhoptry associated protein 1
31. Use of the rhesus monkey as an experimental model to test the efficacy of an anti-sporozoite peptide malaria vaccine candidate combined with copolymer based adjuvants
32. Induction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin
33. Protective immunity induced in squirrel monkeys with a multiple antigen construct (MAC) against the CS protein of Plasmodium vivax
34. Influence of adjuvants on murine immune responses against the C-terminal 19 kDa fragment of Plasmodium vivax merozoite surface protein-1 (MSP-1)
35. Protective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of Plasmodium fragile
36. Human phase 1 trials of 3 recombinant asexual stage malaria antigens with Montanide ISA720 adjuvant
37. Spectrophotometric measurement of dodecyl sulfate with basic fuchin
38. A colorimetric method for determining low concentrations of mercaptans