Structural characterization of contaminants in commercial preparations of melatonin by on-line HPLC-electrospray ionization-tandem mass spectrometry

Advances in Experimental Medicine and Biology

Volumn 467, Issue , 2000, Pages 769-777

  Naylor, S ^a   Johnson, K L ^a   Williamson, B L ^a   Klarskov, K ^a   Gleich, G J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELATONIN;

ACCURACY; CONFERENCE PAPER; EOSINOPHILIA MYALGIA SYNDROME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IONIZATION; ISOMERISM; MASS SPECTROMETRY; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; HYDROXYLATION; MASS SPECTROMETRY; MELATONIN; MOLECULAR STRUCTURE; ONLINE SYSTEMS; TABLETS;

EID: 0034469114     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (24)

1. Alternative medicine-the risks of untested and unregulated remedies
2. Melatonin
3. Improvement of sleep quality in elderly people by controlled-release melatonin
4. Contaminants in L-tryptophan associated with eosinophilia myalgia syndrome
5. Pineal gland: Influence on gonads of male hamsters
6. Applications of liquid chromatography-mass spectrometry in analytical toxicology: A review
7. Melatonin: Media hype or therapeutic breakthrough
8. Melatonin potentially useful but safety. Efficacy remain uncertain
9. Advances in instrumentation in liquid chromatography-mass spectrometry and related liquid-introduction techniques
10. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide
11. Effect of melatonin on jet lag after long haul flights
12. Tryptophan contaminants associated with eosinophilia-myalgia syndrome. The eosinophilia-myalgia studies
13. Melatonin and DHEA: Hormones at your own risk
14. Unraveling the eosinophilia-myalgia syndrome
15. I,1′-ethylidenebis(L-tryptophan), structure determination of contaminant "97" - Implicated in the eosinophilia-myalgia syndrome (EMS)
16. Eosinophilia-myalgia syndrome: Results of national surveillance
17. Eosinophilia-myalgia syndrome: Mortality data from the US national surveillance system
18. Review: Role of Melatonin in health and disease
19. On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome
20. Structural characterization of contaminants found in commercial preparations of melatonin: Similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome
21. On-Line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome
22. Hydroxyl radical-mediated oxidation of serotonin: Potential insights into the neurotoxicity of methamphetamine
23. Statement of the problem: An overview