Effect of perfusate albumin on organ viability and vascular responses in the in vitro dual-perfused rat liver

Journal of Pharmacological and Toxicological Methods

Volumn 43, Issue 3, 2000, Pages 225-231

  Yang, Wenxuan ^a   Benjamin, Irving S ^a   Sherwood, Roy ^b   Salisbury, Jonathan ^b   Alexander, Barry ^a,c  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Albumin; Endothelium response; Liver viability; Perfusate; Rat liver

Indexed keywords

ACETYLCHOLINE; ASPARTATE AMINOTRANSFERASE; BOVINE SERUM ALBUMIN; BUFFER; LACTATE DEHYDROGENASE; METHOXAMINE; NITROPRUSSIDE SODIUM;

ANIMAL TISSUE; ARTICLE; BILE FLOW; BLOOD VESSEL REACTIVITY; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME RELEASE; HEPATIC ARTERY; HEPATIC VEIN; LIVER CELL; LIVER HISTOLOGY; LIVER PERFUSION; LIVER PRESERVATION; LIVER SINUSOID; MALE; NONHUMAN; PORTAL VEIN; RAT; VASODILATATION;

ACETYLCHOLINE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE; HEPATIC ARTERY; L-LACTATE DEHYDROGENASE; LIVER; LIVER CIRCULATION; LIVER FUNCTION TESTS; MALE; NITROPRUSSIDE; PERFUSION; RATS; RATS, WISTAR; SERUM ALBUMIN, BOVINE; VASODILATOR AGENTS;

BOVINAE;

EID: 0034468859     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(00)00106-4     Document Type: Article

References (30)

1. The role of nitric oxide in hepatic metabolism
2. Hepatic function during prolonged rat liver perfusion using a new miniaturized perfusion circuit
3. The dependence of hepatic function upon sufficient oxygen supply during prolonged isolated rat liver perfusion
4. Hypoxia attenuates hepatic arterial vasodilatation and enhances portal venous vasoconstriction to ATP in the perfused rabbit liver
5. An isolated dual-perfused rabbit liver preparation for the study of hepatic blood flow regulation
6. Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia
7. Bile flow - An index of ischemic injury
8. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophathalein sodium (BSP). The role of the bile flow
9. An evaluation of whether duration of perfusion alters vascular responses in the isolated dual-perfused rabbit liver
10. Evidence that S-adenosylmethionine and N-acetylcysteine reduce injury from sequential cold and warm ischemia in the isolated perfused rat liver
11. The isolated perfused rat liver: Conception and protocol consideration
12. Effects of extended cold preservation and transplantation on the rat liver microcirculation
13. A comparison of cold storage solutions for hepatic preservation using the isolated perfused rat liver
14. The effect of colloid concentration on the functional characteristics of isolated perfused rat liver
15. Markers of allograft viability in the rat: Relationship between transplantation and liver function in the isolated perfused liver
16. Isolated perfused rat liver technique
17. An improved technique for isolated perfusion of rat livers and evaluation of perfusates
18. Applications of the isolated perfused rat liver in transplant research
19. Purine nucleoside phosphorylase (PNP) - A new marker for free oxygen radical injury to endothelial cell
20. Localization of purine and pyrimidine nucleoside phosphorylase in heart, kidney, and liver
21. Metabolite des kohlenhydratstoffwechels der isolert perfundierten rattenleber
22. Bile salt and bile formation in rats, rabbits and guinea pigs
23. Protection by albumin against ischaemia and hypoxia-induced hepatic injury
24. Effect of pretransplant flushout of the liver with a solution containing albumin on survival and organ function
25. The isolated perfused rat liver: Preparation and application
26. The isolated dual-perfused rat liver preparation: A new model for the study of the control of hepatic vascular tone
27. Vascular responses of the isolated dual-perfused rat liver to hepatic arterial injections of endothelium-dependent and -independent vasodilators: The correlation to liver viability
28. Correlation of endothelium-dependent and -independent vasodilatation with liver function tests during prolonged perfusion of the rat liver
29. Localization of hepatic vascular resistance sites in the isolated dual-perfused rat liver