Topology of hepatic mitochondrial carnitine palmitoyltransferase I

Advances in Experimental Medicine and Biology

Volumn 466, Issue , 2000, Pages 27-42

  Kashfi, Khosrow ^a,b   Cook, George A ^c  

^a KINGSBOROUGH COMMUNITY COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; ENZYME INHIBITOR; MALONYL COENZYME A; PAPAIN; SUBTILISIN; TRYPSIN;

ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME STRUCTURE; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RAT;

ANIMALS; BINDING SITES; CARNITINE O-PALMITOYLTRANSFERASE; ENZYME INHIBITORS; HUMANS; MITOCHONDRIA, LIVER;

ANIMALIA; STAPHYLOCOCCUS PHAGE 187;

EID: 0034468580     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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6. Carnitine palmitoyltransferase: Location of two enzymatic activities in rat liver mitochondria
7. Malonyl-CoA binding site and overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane
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9. CPTase I: The site of inhibition of fatty acid oxidation by malonyl-CoA
10. Regulation of hepatic fatty acid oxidation and ketone production
11. The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA
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15. 1 values for malonyl-CoA
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17. 1 values
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19. Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase
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21. Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues
22. Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecyglycidate (methyl paloxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria
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25. 14C]malonyl-CoA to rat liver mitochondria after blocking the active site of carnitine palmitoyltransferase I
26. The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase
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32. Yonetani-Theorell analysis of hepatic carnitine palmitoyltransferase-I inhibition indicates two distinct inhibitory binding sites
33. (+)-Hemipalmitoylcarnitinium strongly inhibits carnitine palmitoyltransferase-I in intact mitochondria
34. The Yonetani-Theorell graphical method for examining overlapping subsites of enzyme active centers
35. Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane
36. Isolation of liver or kidney mitochondria
37. Characteristics of isolated and purified preparations of the outer and inner membranes of mitochondria
38. Spectrophotometric and turbidimetric methods for measuring proteins
39. Enzymes as biochemical reagents
40. Subcellular distribution of enzymes determined by rapid digitonin fractionation of isolated hepatocytes
41. The determination of enzyme inhibitor constants
42. Diabetes and proteolysis: Effects on carnitine palmitoyltransferase-I and malonyl-CoA binding