L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions

Advances in Experimental Medicine and Biology

Volumn 467, Issue , 2000, Pages 559-563

  Morita, Toshiko ^a   Saito, Kuniaki ^a   Takemura, Masao ^a   Maekawa, Naoya ^a   Fujigaki, Suwako ^a   Fujii, Hidehiko ^a   Wada, Hisayasu ^a   Takeuchi, Shoji ^a   Noma, Akio ^a   Seishima, Mitsuru ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYANTHRANILIC ACID; CATALASE; KYNURENINE; MANGANESE; SUPEROXIDE DISMUTASE; TRYPTOPHAN;

APOPTOSIS; CONFERENCE PAPER; ENZYME INDUCTION; IMMUNOSTIMULATION; INFLAMMATION; MACROPHAGE; MONOCYTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

3-HYDROXYANTHRANILIC ACID; APOPTOSIS; HUMANS; KYNURENINE; MACROPHAGES; TRYPTOPHAN; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 0034468454     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Oxidation of 3-hydroxyanthranilic acid to the phenoxazinone cinnabarinic acid by peroxy radicals and by compound I of peroxidase or catalase
2. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
3. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity
4. A mechanism for increased quinolinic acid formation following acute systemic immune stimulation
5. 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-cells)