Association of structural changes in the V2 and V3 loops of the gp120 envelope glycoprotein with acquisition of neutralization resistance in a simian-human immunodeficiency virus passaged in vivo

Journal of Virology

Volumn 74, Issue 24, 2000, Pages 11955-11962

  Ye, Y ^a   Zhi Hai Si, ^a   Moore, J P ^a   Sodroski, J ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; GLYCOPROTEIN GP 120; VIRUS ENVELOPE PROTEIN;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; GENETIC CONSERVATION; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS NEUTRALIZATION; VIRUS RESISTANCE;

ANIMALS; BINDING SITES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; PROTEIN CONFORMATION; REASSORTANT VIRUSES; RECEPTORS, VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 0034467915     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.24.11955-11962.2000     Document Type: Article

References (38)

1. Serum neutralization of feline immunodeficiency virus is markedly dependent on passage history of the virus and host system
2. Analysis of the interaction of antibodies with a conserved, enzymatically deglycosylated core of the HIV-1 gp120 envelope glycoprotein
3. Replication and neutralization of human immunodeficiency virus type 1 lacking the V1/V2 variable loops of the gp120 envelope glycoprotein
4. Changes in the HIV-1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)
5. Enhanced sensitivity to neutralizing antibodies in a variant of equine infectious anemia virus is linked to amino acid substitutions in the surface unit envelope glycoprotein
6. Determinants of neutralization resistance in the envelope glycoproteins of a simian-human immunodeficiency virus passaged in vivo
7. Human immunodeficiency virus type I gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein
8. Insertion of primary syncytium-inducing (SI) and non-SI envelope V3 loops in human immunodeficiency virus type 1 (HIV-1) LAI reduces neutralization sensitivity to autologous, but not heterologous, HIV-1 antibodies
9. + T cells and AIDS in pig-tailed macaques
10. Structure of an HIV-1 gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
11. Synergistic neutralization of a chimeric SIV/HIV-1 virus with combinations of human anti-HIV-1 envelope monoclonal antibodies or hyperimmune globulins
12. Persistent infection of macaques with simian-human immunodeficiency viruses
13. mac virus that expresses the HIV-1 envelope glycoproteins
14. Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV)
15. Neutralization sensitivity of cell culture-passaged simian immunodeficiency virus
16. Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1
17. Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus type 1 by using monoclonal antibodies
18. Probing the structure of the V2 domain of the human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: The human immune response to the V1 and V2 domains
19. HIV-1 neutralization: The consequences of viral adaptation to growth on transformed T cells
20. Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein
21. An ELISA for antibodies to the envelope glycoprotein of divergent strains of HIV-1
22. Energetics of the HIV gp120-CD4 binding reaction
23. The neutralizing antibody response to HIV-1: Viral evasion and escape from humoral immunity
24. An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys
25. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
26. SIV/HIV recombinants and their use in studying biological properties
27. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
28. Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies
29. Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
30. Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
31. CD4-dependent, antibody sensitive interactions between HIV-1 and its co-receptor CCR5
32. + target cells is a major mechanism of T cell line-adapted HIV-1 neutralization
33. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR5
34. Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein
35. The antigenic structure of the human immunodeficiency virus gp120 envelope glycoprotein
36. Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding
37. Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions
38. Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region