Human T-lymphotropic virus type 1 p30II functions as a transcription factor and differentially modulates CREB-responsive promoters

Journal of Virology

Volumn 74, Issue 23, 2000, Pages 11270-11277

  Zhang, W ^a   Nisbet, J W ^a   Bartoe, J T ^a   Ding, W ^a   Lairmore, M D ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NUCLEAR PROTEIN; PROTEIN P30; TAX PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; GENE ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REPORTER GENE; TRANSACTIVATION;

ANIMALS; CELL NUCLEUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION; HELA CELLS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; OPEN READING FRAMES; PROMOTER REGIONS (GENETICS); RABBITS; RESPONSE ELEMENTS; TERMINAL REPEAT SEQUENCES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0034467309     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.23.11270-11277.2000     Document Type: Article

References (30)

1. Functional role of pX open reading frame II of human T-lymphotropic virus type 1 in maintenance of viral loads in vivo
2. Expression of alternatively spliced human T-lymphotropic virus type 1 pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers
3. Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines
4. Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: Novel mRNAs and proteins produced by HTLV type I
5. Mitochondrial targeting of the p13(II) protein coded by the x-II ORF of human T-cell leukemia/lymphotropic virus type I (HTLV-I)
6. Selective ablation of human T-cell lymphotropic virus type 1 p12(I) reduces viral infectivity in vivo
7. + lymphocyte transformation and infection in a rabbit model with a molecular clone of human T-cell lymphotropic virus type 1
8. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro
9. Accurate transcription initiation by RNA polymerase in soluble extract from isolated mammalian cell nuclei
10. Human T-cell leukemia viruses: Epidemiology, biology, and pathogenesis
11. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection
12. Antibodies to human T lymphotropic virus type 1 in patients with tropical spastic paresis
13. Molecular features of the human T-cell leukemia virus: Mechanisms of transformation and leukemogenicity
14. Mechanisms of T-cell activation by human T-cell lymphotropic virus type I
15. Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones
16. The p12, p13, and p30 proteins encoded by human T-cell leukemia/lymphotropic virus type-1 open reading frames I and II are localized in three different cellular compartments
17. Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type 1
18. Regulation of the transcription of cyclic AMP-dependent protein kinase
19. Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 tax protein
20. + T lymphocytes
21. HTLV-I associated myelopathy, a new clinical entity
22. Evidence for the chronic in vivo production of human T cell leukemia virus type I Rof and Tof proteins from cytotoxic T lymphocytes directed against viral peptides
23. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
24. The upstream stimulatory factor binds to and activates the promoter of the rat class I alcohol dehydrogenase gene
25. Distinct activation domains within cAMP response element-binding
26. Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes
27. The TAATGARAT motif in the herpes simplex virus immediate-early gene promoter can confer both positive and negative responses to cellular octomer-binding proteins when it is located within the viral genome
28. POU domain transcription factors
29. VP16 targets an amino-terminal domain of HCF involved in cell cycle progression
30. Isolation and characterization of retrovirus from cell lines of human T-cell leukemia and its implication in the disease