Topical amiloride solution accelerates healing of mechanical skin ulcers in albino rats

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 9, 2000, Pages 671-677

  Gupta, B ^a   Singh, N ^a   Saxena, K K ^a   Srivastava, V K ^a  

^a LLRM MEDICAL COLLEGE   (India)

Author keywords

Amiloride; Skin ulcers; Urokinase type plasminogen activator; Wound repair

Indexed keywords

AMILORIDE; UROKINASE;

ALBINISM; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; EXTRACELLULAR MATRIX; NONHUMAN; PROTEIN DEGRADATION; RAT; SKIN BIOPSY; SKIN ULCER; TISSUE INJURY; TISSUE PERFUSION; WOUND HEALING;

ADMINISTRATION, TOPICAL; AMILORIDE; ANIMALS; DIURETICS; FEMALE; MALE; PLASMINOGEN ACTIVATORS; RATS; SKIN ULCER; URINARY PLASMINOGEN ACTIVATOR; WOUND HEALING;

EID: 0034467055     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.9.802282     Document Type: Article

References (32)

1. Wound healing in surgical practice
2. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet derived wound healing factors (PDWHF)
3. Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor
4. Enhancement of wound healing by topical treatment with epidermal growth factor
5. Growth factors and wound healing
6. Topical amiloride accelerates healing and delays neovascularization in mechanically produced corneal ulcers in rabbits
7. Repair and regenerative responses
8. Migrating keratinocytes express urokinase-type plasminogen activator
9. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration daring wound reepithelialization
10. Skin biopsy techniques
11. General Pharmacology
12. Wound Healing
13. Epithelial sheet movement: Protein and glycoprotein synthesis
14. Epithelial sheet movement: Effects of tunicamycin on migration and glycoprotein synthesis
15. Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea
16. Plasmin in the tear fluid of patients with corneal ulcer basis of new therapy
17. Effect of protease inhibitors on corneal epithelial migration
18. Systemic amiloride inhibits experimentally induced neovascularization
19. Plasminogen activator and the membrane of transformed cells
20. Extracellular metabolism of pulmonary surfactant: The role of a new serine protease
21. Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met
22. The interaction of plasma fibronectin with fibroblastic cells in suspension
23. Mechanisms of cell migration in the vertebrate embryo
24. Pathogenesis of corneal epithelial defects: Role of plasminogen activator
25. Wound healing and the plastic surgeon
26. Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor
27. Histochemical study of alkali burned rabbit anterior eye segment in which severe lesions were prevented by aprotinin treatment
28. Polymorphonuclear neutrophils delay corneal epithelial wound healing in vitro
29. Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation
30. Amiloride selectively inhibits the urokinase type plasminogen activator
31. An endogenous sodium current may mediate wound healing in Xenopus neurulae
32. Plasminogen activator purified by immunoaffinity from transformed fibroblasts: Its direct catalytic effects on normal fibroblasts, extracellular matrix and purified fibronectin