Prostaglandin H synthase and lipoxygenase mediated activation of xenobiotics in platelets

Advances in Experimental Medicine and Biology

Volumn 469, Issue , 2000, Pages 631-637

  Lim, K M ^a   Lee, J Y ^a   Kim, J S ^a   Chung, J H ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHOL; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; INDOMETACIN; LIPOXYGENASE; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN SYNTHASE; XENOBIOTIC AGENT;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; COVALENT BOND; DOSE RESPONSE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE;

ANIMALS; ASPIRIN; BIOTRANSFORMATION; BLOOD PLATELETS; CYCLOOXYGENASE INHIBITORS; FEMALE; INDOMETHACIN; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; NAPHTHOLS; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; XENOBIOTICS;

ANIMALIA;

EID: 0034465708     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (15)

1. The role of prostaglandins in platelet function
2. Regeneration of vitamin E in platelets
3. Prostaglandin-H synthase containing cell lines as tools for studying metabolism and toxicity of xenobiotics
4. Peroxidase activation of 1-naphthol to naphthoxy or naphthoxy-derived radicals and their reaction with glutathione
5. Prostaglandin H synthase and xenobiotic oxidation
6. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
7. Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
8. Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: Relationship to inhibition of prostaglandin cyclooxygenase
9. Hydroperoxidase activity of lipoxygenase: Hydrogen peroxide dependent oxidation of xenobiotics
10. Roles of cyclooxygenase and lipoxygenase metabolites in platelets
11. In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: Potential molecular targets of chemical teratogenesis
12. Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates
13. The molecular biology of mammalian arachidonic acid metabolism
14. Mammalian lipoxygenases: Molecular structures and functions
15. Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: In vitro studies using linoleic acid-dependent soybean lipoxygenase and in vivo studies using pregnant CD-1 mice