Effects of naturally occurring flavonoids on inflammatory responses and their action mechanisms

Natural Product Sciences

Volumn 6, Issue 4, 2000, Pages 170-178

  Hyun Pyo Kim, ^a   Kun Ho Son, ^a   Hyeun Wook Chang, ^a   Sam Sik Kang, ^a  

^a Kangwon National University   (South Korea)

Author keywords

Biflavonoid; Cyclooxygenase; Flavone; Flavonoid; Inflammation; Lipoxygenase; Lymphocyte proliferation; Nitric oxide synthase; Phospholipase

Indexed keywords

AMENTOFLAVONE; ANTIINFLAMMATORY AGENT; BIOFLAVONOID; FLAVONOID; GINKGETIN; LIPOXYGENASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; OCHNAFLAVONE; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; CONTROLLED STUDY; ENZYME INHIBITION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; NONHUMAN; PROTEIN EXPRESSION; RAT; REVIEW;

EID: 0034465020     PISSN: 12263907     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. 2 on TNF, iNOS, and COX-2 expression in activated macrophages
2. Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation
3. Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea
4. Protein-tyrosine kinase inhibition: Mechanism-based discovery of antitumor agents
5. 2 by naturally occurring biflavonoid, ochnaflavone
6. In vitro and in vivo inhibitory actions of morin on rat brain phosphatidylinositolphosphate kinase activity
7. Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line, RAW 264.7
8. Effect of wogomin, a plant flavone from scutellaria radix, on the suppression of cyclooxygenace-2 and the induetion of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells
9. 2 superfamily of signal transduction enzymes
10. Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs
11. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structural-activity relationships
12. Anti-inflammatory and antiallergy properties of flavonoids
13. 2 and inflammatory responses in mice
14. 2 with anti-inflammatory activity
15. Flavonoids, a class of natural products of high pharmacological potency
16. Effects of synthetic and naturally occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes
17. Anti-oxidative and anti-inflammatory activities of the mung been
18. Anti-inflammatory activity of flavonoids: Mice ear edema inhibition
19. Amentoflavone, a plant biflavone: New potential anti-inflammatory agent
20. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structural-activity relationships
21. Inhibition of rat adjuvant-induced arthritis by ginkgetin, a plant biflavone from Ginkgo biloba leaves
22. Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs
23. 2 production and cyclooxygenase-2 induction in rat peritoneal macrophages
24. Inhibition of nitric oxide (NO) production in murine macrophages by flavones
25. Inhibition of mammalian 5-lipoxygenase and cyclooxygenase by flavonoids and phenolic dietary additives
26. Anti-inflammatory activity of naturally occurring flavones and flavonol glycosides
27. Anti-inflammatory activity of isoflavonoids from Pueraria radix and biochanin A derivatives
28. Suppression of mouse lymphocyte proliferation in vitro by naturally occurring biflavonoids
29. Inhibition of arachidonate release from rat peritoneal macrophages by biflavonoids
30. Flavonoids
31. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
32. 2 by quercetin
33. Effects of plant flavonoids on immune and inflammatory cell function
34. Nitric oxide: Physiology, pathophysiology, and pharmacology
35. The effects of flavonoids on human lymphocyte proliferative responses
36. Effects of isoflavonoids on mouse lymphocyte proliferation in vitro
37. Effects of naturally-occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture
38. 2, cyclooxygenases, and terminal prostanoid synthases in different phages of prostanoid biosynthesis in rat peritoneal macrophages
39. Nitric oxide as a secretary product of mammalian cells
40. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis
41. Acute and chronic anti-inflammatory effects of plant flavonoids
42. Role of flavonoids in the oxygen-free radical modulation of the immune response
43. A prenylatedflavone, artonin E, as arachidonate 5- lipoxygenase inhibitor
44. Genistein and gut inflammation: Role of nitric oxide
45. Selective inhibition of platelet lipoxygenase by baicalein
46. In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds
47. Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse brain
48. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from the several medicinal plants
49. Vitexicarpin, a plant flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell-lines in vitro