Treatment of brain metastases in patients with small-cell lung cancer: Lessons from treatment of other tumors

Clinical Lung Cancer

Volumn 2, Issue 1, 2000, Pages 29-40

  Wagner H , Jr ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Brain metastases; Chemotherapy; Radiosurgery; Radiotherapy; Small cell lung cancer; Surgery

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CHLORMETHINE; CISPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; LOMUSTINE; METHOTREXATE; PROCARBAZINE; TENIPOSIDE; TOPOTECAN; VINCRISTINE;

AFFECTIVE NEUROSIS; BRAIN INJURY; BRAIN METASTASIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CAUSE OF DEATH; CENTRAL NERVOUS SYSTEM DISEASE; COGNITIVE DEFECT; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CRANIOTOMY; DIGESTIVE SYSTEM ULCER; ERADICATION THERAPY; FAMILY; FATALITY; FLUID RETENTION; GASTROINTESTINAL HEMORRHAGE; HUMAN; HYPERGLYCEMIA; IMMUNE DEFICIENCY; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MULTIMODALITY CANCER THERAPY; MYOPATHY; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; PALLIATIVE THERAPY; PHYSICAL DISEASE; PSYCHOMOTOR DISORDER; QUALITY OF LIFE; RADIATION DOSE FRACTIONATION; RADIOSURGERY; RETROSPECTIVE STUDY; REVIEW; SKULL IRRADIATION; STEREOTAXIC SURGERY; SYMPTOM; THRUSH; TIME OF DEATH; TREATMENT OUTCOME; WHOLE BODY RADIATION;

EID: 0034464684     PISSN: 15257304     EISSN: None     Source Type: Journal    
DOI: 10.3816/clc.2000.n.015     Document Type: Review

References (81)

1. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials
2. The prognostic factors of lung cancer patients with brain metastases treated with radiotherapy
3. Prognostic factors in lung cancer with brain metastasis
4. Brain metastases. Histology, multiplicity, surgery, and survival
5. The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age
6. The value of computed tomographic (CT) scan surveillance in the detection and management of brain metastases in patients with small cell lung cancer
7. Limited value of CT brain scans in the staging of small cell lung cancer
8. MRI in detection of brain metastases at initial staging of small-cell lung cancer
9. Detection of brain metastases: Comparison of contrast-enhanced MR with unenhanced MR and enhanced CT
10. Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): Is MRI useful in initial diagnosis?
11. Should initial treatment of small cell carcinoma include systemic chemotherapy and brain irradiation?
12. CNS metastases in small cell bronchogenic carcinoma: Increasing frequency and changing pattern with lengthening survival
13. Brain metastases in patients with limited small cell lung cancer achieving complete remission
14. Use of corticosteroids in neuro-oncology
15. Treatment of brain metastases from primary lung cancer
16. Should prophylactic anticonvulsants be administered to patients with newly-diagnosed cerebral metastases? A retrospective analysis
17. Prophylactic anticonvulsants for cancer patients with newly diagnosed brain metastases
18. A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors
19. Improved quality of life of patients with small-cell carcinoma of the lung by elective irradiation of the brain
20. Comparison of symptomatic and prophylactic irradiation of brain metastases from oat cell carcinoma of the lung
21. Patients with limited-stage small-cell lung cancer treated with concurrent twice-daily chest radiotherapy and etoposide/cisplatin followed by cyclophosphamide, doxorubicin, and vincristine
22. Brain-only metastases of small cell lung cancer; efficacy of whole brain radiotherapy. An EORTC phase II study
23. Comparison of clinical neurological function and CT response during chemotherapy for initial brain metastases from small cell lung cancer
24. Surgical resection of brain metastases from lung cancer
25. Surgical treatment of multiple brain metastases
26. Stage of the primary is important when treating isolated brain metastases from lung cancer
27. Intraoperative navigation during resection of brain metastases
28. A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis
29. Surgery versus radiosurgery in the treatment of brain metastasis
30. Stereotactic radiosurgery for brain metastases: Comparison of lung carcinoma vs. non-lung tumors
31. Analysis of prognostic factors for patients with single brain metastasis treated with stereotactic radiosurgery
32. Postoperative radiotherapy in the treatment of single metastases to the brain: A randomized trial
33. Focalized external radiotherapy for resected solitary brain metastasis: Does the dogma stand?
34. Prophylactic cranial irradiation in the treatment of small-cell carcinoma of the lung
35. Prophylactic cranial irradiation for patients with small-cell lung cancer
36. Prophylactic cranial irradiation in small-cell lung cancer
37. Should current management of small cell lung cancer include prophylactic cranial irradiation?
38. Management of CNS metastases in small cell lung cancer: A consensus report
39. Prophylactic cranial irradiation for patients with small cell lung cancer. An enduring controversy
40. Prophylactic-cranial irradiation for patients with small-cell lung cancer in complete remission
41. Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: Results of a multicentre randomised trial. United Kingdom Coordinating Committee for Cancer and the European Organization for Research and Treatment of Cancer
42. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission
43. Results of whole-brain irradiation for metastases from small cell carcinoma of the lung
44. Intracranial metastases in small cell carcinoma of the lung
45. Morbidity of cranial relapse in small cell lung cancer and the impact of radiation therapy
46. Teniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lung
47. Results of therapeutic cranial irradiation in small cell lung cancer
48. Irradiation of brain metastases from lung cancer: A retrospective study
49. Therapeutic cranial irradiation in small cell lung cancer
50. Combination chemotherapy for metastatic brain tumors
51. Systemic combination chemotherapy as primary treatment of brain metastasis from lung cancer
52. Brain metastases from small cell lung cancer treated with combination chemotherapy
53. Carboplatin in association with etoposide and either adriamycin or epirubicin for untreated small cell lung cancer: A dose escalation study of carboplatin
54. Resolution of small cell lung cancer intracranial metastases with standard dose chemotherapy
55. Primary chemotherapy of brain metastasis in small-cell lung cancer
56. The response of cerebral metastases in small cell lung cancer to systemic chemotherapy
57. High dose CDDP for brain metastases of lung carcinoma
58. Treatment of brain metastases of lung cancer with high doses of etoposide (VP16-213)
59. Teniposide for brain metastases of small-cell lung cancer: A phase II study
60. High dose etoposide for brain metastases of small cell lung cancer. A phase II study
61. Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: A phase II study in patients with refractory and sensitive disease
62. A randomized trial of surgery in the treatment of single metastases to the brain
63. Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery?
64. A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis
65. Postoperative radiotherapy in the treatment of single metastases to the brain: A randomized trial
66. Radiosurgery for brain metastases: Is whole brain radiotherapy necessary?
67. Management of solitary metastasis to the brain: The role of elective brain irradiation following complete surgical resection
68. Adjuvant radiation therapy after surgical resection of solitary brain metastasis: Association with pattern of failure and survival
69. The role of postoperative radiotherapy after resection of single brain metastases
70. Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases
71. The role of radiation therapy following resection of single brain metastases from melanoma
72. Prophylactic cranial irradiation in small cell carcinoma of the lung. A randomized study
73. Prophylactic cranial irradiation in patients with inoperable carcinoma of the lung: Preliminary report of a cooperative trial
74. A randomized combined modality trial in small cell carcinoma of the lung: Comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy brain irradiation
75. Prophylactic irradiation in bronchogenic small cell anaplastic carcinoma. A comparative trial of localized versus extensive radiotherapy including prophylactic brain irradiation in patients receiving combination chemotherapy
76. Combination chemotherapy for small cell carcinoma of the lung: Continuous versus alternating non-cross-resistant combinations
77. Treatment of small cell lung cancer. Two-drug versus four-drug chemotherapy and loco-regional irradiation with or without prophylactic cranial irradiation
78. Low dose elective brain irradiation in small cell carcinoma of the lung
79. A case for preplanned thoracic and prophylactic whole brain radiation therapy in limited small-cell lung cancer
80. Prophylactic versus no brain irradiation in regional small cell lung carcinoma
81. A randomized phase III trial of prophylactic cranial irradiation (PCI) vs. observation (OBS) in patients (Pts) with small cell lung cancer (SCLC) achieving a complete response: Final report of an incomplete trial Cooperative Oncology Group and Radiation Therapy Oncology Group (E3589/R92-01)