The selective cytotoxicity of γ-linolenic acid (GLA) is associated with increased oxidative stress

Advances in Experimental Medicine and Biology

Volumn 469, Issue , 2000, Pages 493-498

  Vartak, S ^a   Robbins, M E C ^a   Spector, A A ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA LINOLENIC ACID;

ANIMAL CELL; ASTROCYTOMA; CELL CULTURE; CELL PROTECTION; CELL SURVIVAL; CONFERENCE PAPER; CYTOTOXICITY; GLIA CELL; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; RAT; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; ASTROCYTES; ASTROCYTOMA; CELL SURVIVAL; CYCLOOXYGENASE INHIBITORS; DINOPROST; F2-ISOPROSTANES; FATTY ACIDS; GAMMA-LINOLENIC ACID; GLIOMA; IBUPROFEN; LIPOXYGENASE INHIBITORS; OXIDATIVE STRESS; RADIATION TOLERANCE; RATS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034464598     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (13)

1. Cytotoxic action of cis-unsatrated fatty acids on human cervical carcinoma (HeLa) cells: Relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists
2. Effects of dietary primrose oil on mammary tumorigenesis induced by 7,12-dimethylbenz (a) anthracene
3. γ-Linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to "normal" rat astrocytes
4. Vitamin E blocks the cytotoxic effect of γ-linolenic acid when administered as late as the time of onset of cell death-insight into the mechanism of fatty acid induced cytotoxicity
5. Effects of eicosanoid synthesis inhibitors on the in vitro growth and prostaglandin E and leukotriene B secretion of a human breast cancer cell line
6. Eicosanoid synthesis and ornithine decarboxylase activity in mammary tumors of rats fed varying levels and types of N-3 and/or N-6 fatty acids
7. Generation of astrocyte cultures from normal and neoplastic central nervous system
8. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclo-oxygenase, free radical catalyzed mechanism
9. Manganese superoxide dismutase in normal and transformed human embryonic lung fibroblasts
10. Polyunsaturated fatty acids (PUFA) can selectively increase MnSOD levels in normal central nervous system (CNS) derived cells
11. Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation
12. Long-term survival in malignant glioma. Prognostic factors
13. Therapeutic irradiation and brain injury