Effect of different doses of S-adenosyl-L-methionine on paracetamol hepatotoxicity in a mouse model

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 10, 2000, Pages 737-740

  Carrasco, R ^a   Perez Mateo M ^a   Gutierrez A ^a   Esteban, A ^a   Mayol, M J ^a   Caturla, J ^a   Ortiz, P ^a  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

Author keywords

Acetaminophen; N Acetylcysteine; Paracetamol; S Adenosyl L methionine

Indexed keywords

ACETYLCYSTEINE; GLUCURONIDE; PARACETAMOL; S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG OVERDOSE; FEMALE; HUMAN; LIVER NECROSIS; LIVER TOXICITY; MORTALITY; MOUSE;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANIMALS; FEMALE; FREE RADICAL SCAVENGERS; LIVER; LIVER FAILURE; MICE; S-ADENOSYLMETHIONINE;

EID: 0034456930     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.10.802290     Document Type: Article

References (20)

1. Paracetamol poisoning
2. Paracetamol overdosage. Pharmacological considerations and clinical management
3. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning
4. Angioedema with oral N-acetylcysteine
5. Efficacy of N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
6. Clinical use of protective agents after paracetamol overdose
7. S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis
8. Glutathione deficiency in alcoholics: Risk factor for paracetamol hepatotoxicity
9. Inactivation and dissociation of S-adenosyl-methionine synthetase by modification of sulfhydryl groups and its possible occurrence in cirrhosis
10. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism
11. Protective role of S-adenosyl-L-methionine against acetaminophen-induced mortality and hepatotoxicity in mice
12. S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models
13. S-adenosylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase
14. Entrogen-induced cholestasis: Clues to pathogenesis and treatment
15. S-adenosyl-L-methionine (SAMe) improved acetaminophen metabolism in cirrhotic patients
16. Estudio de los niveles plasmáticos de paracetamol y sus metabolitos tras sobrecarga oral o intraperitoneal en el ratós
17. Liver damage and plasma concentrations of paracetamol and its metabolites after paracetamol overdosage in mice
18. Determination of paracetamol and its four metabolites in mouse plasma by reversed-phase ion-pair high-performance liquid chromatography
19. Cimetidine protects against acetaminophen hepatotoxicity in rats
20. The use of N-acetylcysteine long after an acetaminophen overdose in mice