Decrease in gonadotropin-releasing hormone (GnRH) pulse frequency with aging in postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 5, 2000, Pages 1794-1800

  Hall, J E ^a   Lavoie, H B ^a   Marsh, E E ^a   Martin, K A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE;

ADULT; AGED; AGING; ARTICLE; CLINICAL ARTICLE; FEMALE; GONADORELIN RELEASE; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; OVARY FUNCTION; POSTMENOPAUSE; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

ACTIVITY CYCLES; AGED; AGING; BODY MASS INDEX; ESTRADIOL; ESTRONE; FEMALE; FOLLICLE STIMULATING HORMONE; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; GONADOTROPIN-RELEASING HORMONE; HUMANS; LUTEINIZING HORMONE; MIDDLE AGED; POSTMENOPAUSE;

EID: 0034455736     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.5.1794     Document Type: Article

References (44)

1. Follicular depletion during the menopausal transition: Evidence for accelerated loss and ultimate exhaustion
2. Aging of the female reproductive system: A window into brain aging
3. The effect of ovariectomy on gonadotropin release
4. Regulation of human gonadotropins. XIII. Changes in serum gonadotropins in menstruating women in response to oophorectomy
5. Plasma hormone profiles after the menopause and bilateral oophorectomy
6. Hormone profiles after the menopause
7. Serum gonadotropins and α-subunit decline in aging normal postmenopausal women
8. Gonadotropin secretion during aging in postmenopausal women
9. Pituitary LH and FSH secretion and responsiveness in women of old age
10. The effect of aging on hypothalamic function in oophorectomized women
11. Post-menopausal and chronological age have divergent effects on pituitary and hypothalamic function in episodic gonadotrophin secretion
12. The temporal relationship between gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes
13. Central electrophysiologic correlates of pulsatile luteinizing hormone secretion in the rhesus monkey
14. Neuroendocrine regulation of the luteinizing hormone-releasing hormone pulse generator in the rat
15. Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: Existence of a preovulatory GnRH surge
16. Effects of aging and gonadal failure on the hypothalamic-pituitary axis in women
17. Administration of low dose pulsatile gonadotropin-releasing hormone (GnRH) to GnRH-deficient men regulates free α-subunit secretion
18. Differential regulation of luteinizing hormone, follicle-stimulating hormone, and free α-subunit secretion from the gonadotrope by gonadotropin-releasing hormone (GnRH): Evidence from the use of two GnRH antagonists
19. Utility of free α-subunit as an alternative neuroendocrine marker of gonadotropin-releasing hormone (GnRH) stimulation of the gonadotroph in the human: Evidence from normal and GnRH-deficient men
20. Thyroid hormone, oestrogen, and glucocorticoid effects on two different pituitary glycoprotein hormone alpha subunit pools
21. Metabolic clearance and secretion rates of subunits of human thyrotropin
22. Disappearance of endogenous luteinizing hormone is prolonged in postmenopausal women
23. Free α-subunit is superior to luteinizing hormone as a marker of gonadotropin-releasing hormone despite desensitization at fast pulse frequencies
24. The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency
25. Neuroendocrine regulation of the corpus luteum in the human
26. Improved measurement of free α subunit of glycoprotein hormones by assay with use of a monoclonal antibody
27. The biologic activity of a potent analogue of gonadotropin releasing hormone in normal and hypogonadotropic men
28. Cluster analysis: A simple, versatile, and robust algorithm for endocrine pulse detection
29. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle
30. Endocrinology and aging
31. Pulsatile gonadotropin secretion during the human menstrual cycle: Evidence for altered frequency of gonadotropin-releasing hormone secretion
32. The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women
33. Pulsatile secretion of immunoreactaive α-subunit secretion in man
34. Hypophyseal responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone
35. Effects of increasing the frequency of low doses of gonadotropin-releasing hormone (GnRH) on gonadotropin secretion in GnRH-deficient men
36. Studies on the metabolic clearance rate and production rate of human luteinizing hormone and on the initial half-time of its subtmits in man
37. Mode of pulsatile follicle-stimulating hormone secretion in gonadal hormone-sufficient and -deficient women - A clinical research center study
38. Relative changes in LH pulsatility during the menstrual cycle: Using data from hypogonadal women as a reference point
39. Does the gonadotropin pulsatility of postmenopausal women represent the unrestrained hypothalamic-pituitary activity?
40. Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy
41. Changes in reproductive hormones and sex hormone-binding globulin in a group of postmenopausal women measured over 10 years
42. How do androgens affect episodic gonadotrophin secretion in postmenopausal women?
43. Interpulse interval of GnRH stimulation independently modulates LH secretion