Hemodynamic, hormonal, and renal effects of short-term adrenomedullin infusion in healthy volunteers

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 3, 2000, Pages 1016-1020

  Lainchbury, John G ^a   Troughton, Richard W ^a   Lewis, Lynley K ^a   Yandle, Timothy G ^a   Richards, A Mark ^a   Nicholls, M Gary ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ADRENOMEDULLIN; ALDOSTERONE; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CYCLIC AMP; HYDROCORTISONE; NORADRENALIN; POLYGELINE; PROLACTIN; RENIN;

ADULT; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HEART OUTPUT; HEART RATE; HEMODYNAMICS; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; KIDNEY FUNCTION; MALE; NORMAL HUMAN; PATHOPHYSIOLOGY; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; SODIUM EXCRETION; URINE VOLUME;

ADOLESCENT; ADRENOMEDULLIN; ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; HEART RATE; HEMODYNAMIC PROCESSES; HORMONES; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; PEPTIDES; RECOMBINANT PROTEINS; URODYNAMICS; VASODILATOR AGENTS;

EID: 0034452959     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.3.1016     Document Type: Article

References (47)

1. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
2. Genomic structure of human adrenomedullin gene
3. Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma
4. Novel sites of adrenomedullin gene expression in mouse and rat tissues
5. Endothelial cells actively synthesize and secrete adrenomedullin
6. Adrenocortical steroids, thyroid hormones and retinoic acid augment the production of adrenomedullin in vascular smooth muscle cells
7. Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells
8. Regulation of adrenomedullin production in rat endothelial cells
9. Adrenomedullin
10. Characterization of immunoreactive adrenomedullin in human plasma and urine
11. Increased plasma adrenomedullin levels in chronic congestive heart failure
12. Immunoreactive adrenomedullin in human plasma
13. Plasma adrenomedullin in diabetes
14. Increased adrenomedullin levels in cirrhosis: Relationship with hemodynamic abnormalities and vasoconstrictor systems
15. Increased plasma levels of adrenomedullin in patients with pulmonary hypertension
16. Increased plasma concentration of adrenomedullin in patients with subarachnoid hemorrhage
17. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis
18. Elevated plasma adrenomedullin level in hyperthyroidism
19. Increased plasma adrenomedullin concentrations during cardiac surgery
20. Adrenomedullin in pregnancy
21. Adrenomedullin: Vascular hormone
22. Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake
23. Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: A pharmacokinetic study
24. Adrenomedullin: A hypotensive hormone in man
25. Adrenomedullin (1-52) measured in human plasma by radioimmunoassay: Plasma concentration, adsorption, and storage
26. Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers
27. A direct radioimmunoassay for aldosterone in plasma
28. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man
29. Assay of brain natriuretic peptide (BNP) in human plasma: Evidence for high molecular weight BNP as a major plasma component in heart failure
30. Renal, endocrine, and hemodynamic interactions of atrial and brain natriuretic peptides in normal men
31. Production of a monoclonal antibody to cortisol: Application to a direct enzyme-linked immunosorbent assay of plasma
32. P2Y analysis of variance and covariance including repeated measures
33. Adrenomedullin: A newly discovered hormone controlling fluid and electrolyte homeostasis
34. Adrenomedullin stimulates renin release and renin mRNA in mouse juxtaglomerular granular cells
35. Adrenomedullin and CGRP receptors mediate different effects in the rat adrenal cortex
36. Effect of adrenomedullin on aldosterone secretion by dispersed rat adrenal zona glomerulosa cells
37. Adrenomedullin and calcitonin gene-related peptide inhibit aldosterone secretion in rats, acting via a common receptor
38. Effects of adrenomedullin and proadrenomedullin N-terminal 20 peptide on rat zona glomerulosa cells
39. Effects of adrenomedullin on the human adrenal glands: An in vitro study
40. Inhibitory, effect of adrenomedullin (ADM) on the aldosterone response of human adrenocortical cells to angiotensin-II: Role of ADM(22-52)-sensitive receptors
41. Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells
42. 2+ mobilization, in bovine aortic endothelial cells
43. Adrenomedullin acts via stimulation of cyclic AMP and not via calcium signalling in vascular cells in culture
44. Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels
45. Inotropic effect of adrenomedullin in the isolated perfused rat heart
46. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide
47. Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure