IgE isotype determination: ε-germline gene transcription, DNA recombination and b-cell differentiation

British Medical Bulletin

Volumn 56, Issue 4, 2000, Pages 908-924

  Gould, Hannah J ^a   Beavil, Rebecca L ^a   Vercelli, Donata ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; STAT PROTEIN;

ALLERGY; ANTIBODY PRODUCTION; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; BINDING AFFINITY; DNA BINDING; DNA RECOMBINATION; GENETIC TRANSCRIPTION; GERM LINE; MAST CELL; PRIORITY JOURNAL; REVIEW; RNA SPLICING;

ANTIBODIES; B-LYMPHOCYTES; CELL DIFFERENTIATION; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN E; IMMUNOGLOBULIN EPSILON-CHAINS; IMMUNOGLOBULIN ISOTYPES; RECOMBINATION, GENETIC; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION, GENETIC;

EID: 0034445835     PISSN: 00071420     EISSN: None     Source Type: Journal    
DOI: 10.1258/0007142001903599     Document Type: Review

References (53)

1. Molecular mechanisms of T-cell switching
2. Th-2 cytokines in allergic disease
3. Regulation of ε-germline gene transcription: Q and A
4. Cytokine signal transduction and its role in isotype class switching
5. Molecular mechanisms of immunoglobulin E regulation
6. IgE in asthma and atopy: Cellular and molecular connections
7. Regulation of the IgE isotype switch: New insights on cytokine signals and the functions of ε germline transcripts
8. IL-4/IL-13 signaling beyond JAK/STAT
9. CD40 cross-linking induces Igε germline transcripts in B-cells via activation of NF-κB: Synergy with IL-4 induction
10. Interaction of Stat6 and NF-κB: Direct association and synergistic activation of interleukin-4-induced transcription
11. Functional synergism of STAT6 with either NF-κB or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription
12. Overexpression of BSAP/Pax5 inhibits switching to IgA and enhances switching to IgE in the 1.29μ B-cell line
13. Mechanism and regulation of immunoglobulin isotype switching
14. Antibody class switching
15. Switch transcripts and cytokine regulation of class switching
16. Class switch recombination: Mechanism and specificity
17. Molecular processes that regulate class switching
18. The mechanism of V(D)J joining: Lessons from molecular immunological, and comparative analyses
19. Recent advances in understanding V(D)J recombination
20. V(D)J recombination: On the cutting edge
21. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
22. Mechanisms of V(D)J recombination
23. Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
24. Guardians of the genome
25. Unequal access: Regulating V(D)J recombination through chromatin remodelling
26. The immunoglobulin class switch: Beyond 'accessibility'
27. Multiple types of chimeric germ-line Ig heavy chain transcripts in human B-cells: Evidence for trans-splicing of human Ig RNA
28. Unique and unprecedented recombination mechanism in class switching
29. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
30. What to do at an end: DNA double-strand-break repair
31. DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK
32. DNA end-joining: From yeast to man
33. DNA double-strand break repair
34. Ku protein stimulates DNA end joining by mammalian ligases: A direct role for Ku in repair of DNA double-strand breaks
35. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
36. A mechanistic basis for Mre11-directed DNA joining at microhomologies
37. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
38. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B-cells
39. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
40. Activation-induced cytidine deaminase (AID) deficiency causes autosomal recessive form of the hyper-IgM syndrome
41. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene
42. Fortifying B-cells with CD154: An engaging tale of many hues
43. IgE homeostasis: Is CD23 the safety switch?
44. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation
45. + B-cell line
46. Cell division number regulates IgG1 and IgE switching of B-cells following stimulation by CD40 ligand and IL-4
47. Cell cycle regulation of germline immunoglobulin transcription: Potential role of ets family members
48. Regulation of cell morphology in B lymphocytes by IL-4: Evidence for induced cytoskeletal changes
49. Interleukin IL-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naïve B lymphocytes
50. Recombinant 25 kDa CD23 and interleukin 1α promote the survival of germinal center B-cells: Evidence for bifurcation in the development of centrocytes rescued from apoptosis
51. CD21 is a ligand for CD23 and regulates IgE production
52. Inhibition of IgE receptor interactions
53. Function of CD23 in the response of human B-cells to antigen