Monoclonal anti-GD3 antibodies selectively inhibit the proliferation of human malignant glioma cells in vitro

Glycoconjugate Journal

Volumn 17, Issue 10, 2000, Pages 717-726

  Hedberg, K M ^a   Dellheden, B ^a   Wikstrand, C J ^b   Fredman, P ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b DUKE UNIVERSITY   (United States)

Author keywords

Carbohydrate antigens; Gangliosides; Glioma; Monoclonal antibodies; Proliferation

Indexed keywords

GANGLIOSIDE ANTIBODY; GANGLIOSIDE GD3; GANGLIOSIDE GD3 ANTIBODY; GANGLIOSIDE GM2; GANGLIOSIDE GM2 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; GLIOMA CELL; GROWTH REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; CELL DIVISION; CENTRAL NERVOUS SYSTEM NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; G(M2) GANGLIOSIDE; GANGLIOSIDES; GLIOMA; HUMANS; NECROSIS; THYMIDINE; TUMOR CELLS, CULTURED;

EID: 0034445003     PISSN: 02820080     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011026823362     Document Type: Article

References (58)

1. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens
2. Lipid composition of human neural tumors
3. Gangliosides in human malignant gliomas
4. The presence of fetal ganglioside antigens, 3′-isoLM1 and 3′6′-isoLD 1, in both glioma tissue and surrounding areas from human brain
5. Human brain gangliosides: Developmental changes from early fetal stage to advanced age
6. Gangliosides in the human glioma cell line U-118 MG grown in culture or as xenografts in nude rats
7. Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling
8. Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line
9. Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: A phase I trial in patients with malignant melanoma
10. Treatment of patients with malignant melanoma by monoclonal ganglioside antibodies
11. Inhibition of human melanoma cell growth in vitro by monoclonal anti-GD3-ganglioside antibody
12. Human monoclonal antibody to tumor-associated ganglioside GD2: Suppressed growth of human melanoma in nude mice
13. Ganglioside GD2 specific monoclonal antibody 3F8: A phase 1 study in patients with neuroblastoma and malignant melanoma
14. Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro
15. Effects of EGF, bFGF, NGF and PDGF(bb) on cell proliferative, migratory and invasive capacities of human brain-tumour biopsies in vitro
16. Heterogeneous response to the growth factors (EGF PDGF(bb), TGF-α, bFGF, IL-2) on glioma spheroid growth, migration and invasion
17. Ganglioside modulation of the PDGF receptor
18. Association of Src family tyrosine kinase Lyn with ganglioside GD3 in rat brain
19. New insights in glycosphingolipid function: "glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling
20. Lipid composition of human glial tumour and adjacent brain
21. Gangliosides in human brain tumours
22. Gangliosides of human cerebral astrocytomas
23. Gangliosides and neutral glycosphingolipids in human brain tumors: Specificity and their significance
24. Correlation between ganglioside distribution and histological grading of human astrocytomas
25. Potential ganglioside antigens associated with human gliomas
26. Expression of gangliosides GD3 and 3′-isoLM1 in autopsy brains from patients with malignant tumors
27. Composition of gangliosides and neutral glycosphingolipids of brain in classical Tay-Sachs and Sandhoff disease: More lyso-GM2 in Sandhoff disease?
28. Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line
29. Trisialosyllactosyl-ceramide (GT3) is a ganglioside of human lung
30. Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2
31. A new ganglioside of the lactotetraose series, Gal-NAc-3′-soLM1, detected in human meconium
32. GD3 expression by cultured human tumor cells of neuroectodermal origin
33. Synthesis, surface deposition, and secretion of immunoglobulins by Abelson virus-transformed lymphosarcoma cell lines
34. Inward rectifying potassium channels in human malignant glioma cells
35. In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors
36. Demonstration of complex antigenic heterogeneity in a human glioma cell line and eight derived clones by specific monoclonal antibodies
37. Long term culture of normal and neoplastic human glia
38. Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines
39. Establishment of three human renal cell carcinoma cell lines (SMKT-R-1, SMKT-R-2, and SMKT-R-3) and their characters
40. Measurement of protein using bicinchoninic acid
41. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
42. S-phase cell detection with a monoclonal antibody
43. Cell-cycle analysis using a monoclonal antibody to BrdUrd
44. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
45. An enzyme-linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures
46. A procedure for the quantitative isolation of brain gangliosides
47. Ganglioside composition in human meningiomas
48. Separation of gangliosides on a new type of anion-exchange resin
49. Isolation and structural determination of a novel ganglioside, a disialosylpentahexosylceramide from human brain
50. Comparison of receptors for Cholera and Escherichia coli enterotoxins in human intestine
51. Cell density-dependent changes of glycolipid concentrations in fibroblasts, and loss of this response in virus-transformed cells
52. Glycolipid synthesis in normal and virus-transformed hamster cell lines
53. Down-regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression in hamster melanoma cells: Effect on cellular growth, melanogenesis, and dendricity
54. Decreased synthesis of glycosphingolipids in cells lacking vimentin intermediate filaments
55. Detection of glioma-associated gangliosides GM2, GD2, GD3, 3′-isoLM1 and 3′6′-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies
56. Glycolipid-enriched caveolae and caveolae-like domains in the nervous system
57. Commission on Biochemical Nomenclature (CBN): The nomenclature of lipids
58. Chromatographic separation of human brain gangliosides