Severe thrombotic complications associated with activated protein C resistance acquired by orthotopic liver transplantation

Haemostasis

Volumn 30, Issue 6, 2000, Pages 316-320

  Gillis, Shmuel ^a   Lebenthal, Avi ^a   Pogrebijsky, Galina ^a   Levy, Yizhar ^a   Eldor, Amiram ^b   Ahmed, Eid ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Activated protein C resistance; Factor V Leiden; Liver transplantation; Thrombosis

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 5;

ACTIVATED PROTEIN C RESISTANCE; ADULT; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; CASE REPORT; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DONOR; GENE MUTATION; HUMAN; LIVER TRANSPLANTATION; MALE; MEGAKARYOCYTE; PERIPHERAL BLOOD STEM CELL; POSTOPERATIVE THROMBOSIS; PRIORITY JOURNAL;

EID: 0034444433     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054149     Document Type: Article

References (16)

1. Bertina RM, Koelman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67.
2. Tracy PB, Eide LL, Bowie EJW, Mann KG: Radioimmunoassay of factor V in human plasma and platelets. Blood 1982;60:59-63.
3. Camire RM, Pollak ES, Kaushansky K, Tracy PB: Secretable human platelet-derived factor V originates from the plasma pool. Blood 1998; 92:3035-3041.
4. Gewirtz AM, Shapiro C, Shen YM, Boyd R, Colman RW: Cellular and molecular regulation of factor V expression in human megakaryocytes. J Cell Physiol 1992;153:277-287.
5. Jorquera JL, Montoro JM, Fernandez MA, Aznar JA, Aznar J: Modified test for activated protein C resistance. Lancet 1994;344:1162-1163.
6. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R: A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
7. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing JB: Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999;340:9-13.
8. Velasco F, Villalba R, Fernandez M, de la Mata M, Roman J, Rubio V, Rufian S, Varo E, Pera C, Torres A: Diminished anticoagulant and fibrinolytic activity following liver transplantation. Transplantation 1992; 53:1256-1261.
9. Eid A, Lyass S, Venturero M, Ilan Y, Safadi R, Zamir G, Berlatzky Y, Yurim O: Vascular complications post orthotopic liver transplantation. Transplant Proc 1999;31:1903-1904.
10. Hirshfield G, Collier JD, Brown K, Taylor C, Frick T, Baglin TP, Alexander GJ: Donor factor V Leiden mutation and vascular thombosis following liver transplantation. Liver Transpl Surg 1998;4:58-61.
11. Delorme MA, Adams PC, Grant D, Ghent C, Walker IR, Wall WJ: Orthotopic liver transplantation in a patient with combined hemophilia A and B. Am J Hematol 1990;33: 136-138.
12. Clarkson K, Rosenfeld B, Fair J, Klein A, Bell W: Factor XI deficiency acquired by liver transplantation. Ann Intern Med 1992;115:877-879.
13. Cransac M, Carles J, Bernard PH, Malavialle P, Freyburger G, Winnock S, Saric J: Heterozygous protein C deficiency and dysfibrinogenemia acquired by liver transplantation. Transplant Int 1995;8:307-311.
14. Blanshard C, Pasi J, Rolles K, Davidson B, Jain S, Burroughs A: Acute Budd-Chiari syndrome treated by liver transplantation in a woman homozygous for factor V Leiden. Eur J Gastroenterol Hepatol 1996;8:925-927.
15. Foster PA, Varma RR: Phenotypic correction of activated protein C resistance following orthotopic liver transplantation. Blood Coagul Fibrinolysis 1996;7:65-68.
16. Mandel H, Brenner B, Berant M, Rosenberg N, Lanir N, Jakobs C, Fowler B, Seligsohn U: Coexistence of hereditary homocystinuria and factor V Leiden - effect on thrombosis. N Engl J Med 1996;334:763-768.