Quantitative autoradiography of adrenergic, neuropeptide Y and angiotensin II receptors in the nucleus tractus solitarii and hypothalamus of rats with experimental hypertension

General Pharmacology: The Vascular System

Volumn 34, Issue 5, 2000, Pages 343-348

  Almeida, Renato S ^a   Ferrari, Merari F R ^a   Fior Chadi, Debora R ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Alpha adrenoceptor; Angiotensin II; Autoradiography; Brain; Neuropeptide Y; Receptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; APRACLONIDINE; CATECHOLAMINE; IODINE 125; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NORADRENALIN; PEPTIDE YY; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR HYPOTHALAMUS; AORTA COARCTATION; ARTERIAL PRESSURE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RADIOASSAY; RAT; RECEPTOR BINDING; SOLITARY TRACT NUCLEUS;

ADRENERGIC AGENTS; ANIMALS; AORTIC COARCTATION; AUTORADIOGRAPHY; BINDING SITES; BINDING, COMPETITIVE; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; EVALUATION STUDIES; HYPERTENSION; MALE; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR; RECEPTORS, ANGIOTENSIN; SOLITARY NUCLEUS;

EID: 0034442638     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(00)00080-X     Document Type: Article

References (29)

1. Aicher, S.A., Springston, M., Berger, S.B., Reis, D.J., Wahlestedt, C., 1991. Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain. Neurosci. Lett. 130, 32-36.
2. Bachelard, H., Harland, D., Gardiner, S.M., Kemp, P.A., Benne, T., 1992. Regional haemodynamic effects of noradrenaline injected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats: possible mechanisms of action. Neuroscience 47, 941-957.
3. Banaco, R.A., Ergene, E., Dunbar, J.C., El-Ridi, M.R., 1990. Cardiores-piratory response patterns elicited by microinjections of neuropeptide Y in the nucleus tractus solitarius. Brain Res. Bull. 24, 465-485.
4. Dampney, R.A.L., 1994. Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 74, 323-364.
5. Dijk, G.V., Bottone, A.E., Strubbe, J.H., Steffens, A.B., 1994. Hormonal and metabolic effects of paraventricular hypothalamic administration of neuropeptide Y during rest and feeding. Brain Res. 660, 96-103.
6. Everitt, B., Hokfelt, T., Terenius, L., Tatemoto, K., Mutt, V, Goldstein, M., 1984. Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 11, 443-462.
7. Ferguson, A., Washburn, D., 1998. Angiotensin II: a peptidergic neurotransmitter in central autonomie pathways. Prog. Neurobiol. 54, 169-192.
8. Fior, D.R., Yang, S.-N., Hedlund, P.B., Narváez, J.A., Agnati, L.F., Fuxe, K., 1994. Evidence for an antagonistic angiotensin II: a2-interaction in the nucleus tractus solitarii. Eur. J. Pharmacol. 262, 271-282.
9. Harland, D., Gardiner, S.M., Bennett, T., 1989. Paraventricular nucleus injections of noradrenaline: cardiovascular effects in conscious Long-Evans and Brattleboro rats. Brain Res. 496, 14-24.
10. Krieger, E., 1970. Time course of baroreceptor resetting in acute hypertension. Am. J. Physiol. 218, 486-490.
11. Lappe, R.W., Brody, M.J., 1986. Hemodynamic, neural, and humoral mechanisms of aortic coarctation hypertension in the rat. J. Cardiovasc. Pharmacol. 8, 656-662.
12. Lawrence, J.A., Jarrot, B., 1996. Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius. Prog. Neurobiol. 48, 21-53.
13. Martire, M., Fuxe, K., Pistrito, G., Preziosi, P., Agnati, L., 1986. Neuropeptide Y enhances the inhibitory effecs of clonidine on 3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat. J. Neural Transm. 67, 113-124.
14. Morulsky, H.J., Ransnas, L.A., 1987. Fitting curves to data using nonlinear regression: a practical and nonmathematical review. FASEB J. 1, 365-374.
15. Parker, R.M.C., Herzog, H., 1999. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur. J. Neurosci. 11, 1431-1448.
16. Pavia, J., Hastings, J., Morris, M., 1995. Neuropeptide Y potentiation of potassium-induced noradrenaline release in the hypothalamic paraventricular nucleus of the rat in vivo. Brain Res. 690, 108-111.
17. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
18. Peach, M., 1977. Renin-angiotensin system: biochemistry and mechanism of action. Physiol. Rev. 57, 313-370.
19. Salgado, H.C., Salgado, M.C., 1989. Acute aortic coarctation hypertension: role of vasopressin and angiotensin II. Am. J. Physiol. 257, H1480-H1484.
20. Salgado, H.C., Fazan Jr., R., Machado, B.H., Salgado, M.C. 1992. Mechanical and neurohumoral factors in acute aortic coarctation hypertension. Agents Actions Suppl. 36, 152-163.
21. Santos, C., Pontieri, V, Leomil Neto, M., Michelini, L., 1995. Losartan improves baroreflex control of heart rate of coarcted hypertensive rats. Am. J. Physiol. 269, H812-H818.
22. Sato, K., Crofton, J.T., Wang, Y.X., Share, L., 1995. Effects of gender on the central actions of neuropeptide Y and norepinephrine on vasopressin and blood pressure in the rat. Brain Res. 689, 71-78.
23. Sweet, C.S., Columbo, J.M., Gaul, S.L., 1976. Central antihypertensive effects of inhibitors of the renin-angiotensin system in rats. Am. J. Physiol. 231, 1794-1799.
24. van Giersbergen, P.L.M., Palkovits, M., De Jong, W., 1992. Involvement of neurotransmitters in the nucleus tractus solitarii in cardiovascular regulation. Physiol. Rev. 72, 789-824.
25. Woo, N., Ganguly, P., 1994. Altered neuropeptide Y effects on noradrenaline levels in the paraventricular nucleus of rats following aortic constriction. Can. J. Cardiol. 10, 471-476.
26. Yang, S.-N., Narváez, J.A., Bjelke, B., Agnati, L.F., Fuxe, K., 1993. Microinjections of subpicomolar amounts of NPY (13-36) into the nucleus tractus solitarius of the rat counteract the vasodepressor responses of NPY (1-36) and of a Y| receptor agonist. Brain Res. 621, 126-132.
27. 34] NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline. Neurosci. Lett. 171, 27-31.
28. Yang, S.-N., Bjelke, B., Narvácz, J.A., Cintra, A., Agnati, L.F., Fuxe, K.,
29. 2-adrenoceptor function in the nucleus tractus solitarii of the spontaneously hypertensive rat. Neuroscience 78, 803-813.