Application of in vitro-in vivo correlations (IVIVC) in setting formulation release specifications

Biopharmaceutics and Drug Disposition

Volumn 21, Issue 8, 2000, Pages 321-326

  Modi, Nishit B ^a   Lam, Andrew ^a   Lindemulder, Elizabeth ^a   Wang, Bei ^a   Gupta, Suneel K ^a  

^a ALZA CORPORATION   (United States)

Author keywords

Formulation release specifications; In vitro in vivo correlations; OROS system

Indexed keywords

DRUG;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CORRELATION FUNCTION; DATA ANALYSIS; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG RESEARCH; DRUG SOLUBILITY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MEDICAL TECHNOLOGY; NORMAL HUMAN; OSMOSIS; STATISTICAL ANALYSIS; VALIDATION PROCESS;

ALGORITHMS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; PHARMACOKINETICS; SOLUBILITY;

EID: 0034434385     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.248     Document Type: Article

References (17)

1. In vitro-in vivo correlation, a time scaling problem?
2. In vitro-in vivo correlation of dissolution, a time scaling problem? Transformation of in vitro results to the in vivo situation, using theophylline as a practical example
3. Evaluation of in vivo drug release by numerical deconvolution using oral solution data as weighting function
4. In vitro-in vivo correlation for modified-release formulations
5. Level A in vivo-in vitro correlation: Nonlinear models and statistical methodology
6. New evaluation method for in vitro/in vivo correlation of enteric-coated multiple unit dosage forms
7. In vivo evaluation of controlled-release products
8. In vitro and in vivo correlation for controlled-release formulation of d-chlorphenirame maleate
9. The elementary osmotic pump
10. Single and multiple-dose pharmacokinetics of an oral once-a-day osmotic controlled release OROS® (methylphenidate HCl) formulation
11. Pharmacokinetics of an oral once-a-day controlled-release oxybutynin formulation compared with immediate-release oxybutynin
12. Feasibility and functionality of OROS melatonin in healthy subjects
13. Pharmacokinetic and pharmacodynamic characterization of OROS and immediate-release amitriptyline
14. Linear systems analysis in pharmacokinetics
15. An algorithm for constrained deconvolution based on reparameterization
16. Convolution-based approaches for in vivo-in vitro correlation modeling
17. Gastrointestinal bioavailability: Determination of in vivo release profiles of solid oral dosage forms by deconvolution