Dose-dependent pharmacokinetics of a new neuroprotective agent for ischemia-reperfusion damage, KR-31378, in rats

Biopharmaceutics and Drug Disposition

Volumn 21, Issue 7, 2000, Pages 279-284

  Kim, Hee J ^a   Kim, So H ^a   Kim, Sun O ^b   Lee, Dong H ^b   Lim, Hong ^b   Yoo, Sung E ^c   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b Dongbu Hannong Chemical Co   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

KR 31378; Pharmacokinetics; Rats

Indexed keywords

DRUG METABOLITE; KR 31378; KR 31612; N'' CYANO N (6 AMINO 3,4 DIHYDRO 3 HYDROXY 2 METHYL 2 DIMETHOXYMETHYL 2H BENZOPYRAN 4 YL) N' BENZYLGUANIDINE; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; LIVER; MALE; NONHUMAN; PARAMETER; RAT; REPERFUSION INJURY;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINES; MALE; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 0034434239     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.240     Document Type: Article

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