Synthesis of tetracyclic benzodioxins as potential antitumour agents

Anti-Cancer Drug Design

Volumn 15, Issue 6, 2000, Pages 453-458

  Spicer, J A ^a   Denny, W A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Anticancer drug; Dibenzodioxin; Oxanthrene; Tricyclic carboxamide

Indexed keywords

1,2 NAPHTHALENEDIOL; 7,8 DIHYDROXYISOQUINOLINE; 7,8 DIHYDROXYQUINOLINE; AMIDE; BENZODIOXAN DERIVATIVE; BENZOIC ACID DERIVATIVE; BENZOIC ACID ESTER DERIVATIVE; CYTOTOXIC AGENT; ISOPROPYL 2 CHLORO 3 NITROBENZOATE; N [2 (DIMETHYLAMINO)ETHYL][1,4]BENZODIOXINO[2,3 H]ISOQUINOLINE 11 CARBOXAMIDE; N [2 (DIMETHYLAMINO)ETHYL][1,4]BENZODIOXINO[2,3 H]ISOQUINOLINE 8 CARBOXAMIDE; NAPHTHALENE DERIVATIVE; PHENAZINE DERIVATIVE; QUINOLINE DERIVATIVE; TETRACYCLIC BENZODIOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; LEUKEMIA CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIOXINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE;

EID: 0034434221     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. New modification of the Pomeranz-Fritsch isoquinoline synthesis
2. Synthesis and cytotoxic activity of benzodioxinic derivatives
3. Cyanodibenzo[1,4]-dioxines: A new family of synthons for substituted dibenzo[1,4]dioxins
4. From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives
5. Synthesis of bridgehead hydroxyl-substituted benzobicyclo[3.2.1]octenes and -octadienes via an acyloin rearrangement in the benzobicyclo[2.2.2]octene ring system
6. Convenient syntheses of substituted 7,12-dioxa-benzo[a]anthracenes and 7,12-dioxa-5-aza-benzo[a]anthracenes
7. An improved synthesis of substituted dibenzo[1,4]dioxins
8. Potential antitumor agents. 64. Synthesis and antitumor evaluation of dibenzo[1,4]dioxin-1-carboxamides, a new class of weakly-binding DNA-intercalating agents
9. Boron tribromide - A powerful demethylating reagent for aromatic ethers
10. A preparation of 7,8-dihydroxyquinoline
11. Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of tricyclic carboxamides
12. Potential antiumor agents. 51. Synthesis and antitumor activity of phenazine-1-carboxamides
13. Oxidations with potassium nitrosodisulfonate (Fremy's radical). Teuber reaction