Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy

Immunogenetics

Volumn 52, Issue 1-2, 2000, Pages 12-18

  Miyagawa, Taku ^a   Hohjoh, Hirohiko ^a   Honda, Yutaka ^b   Juji, Takeo ^c   Tokunaga, Katsushi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SEIWA HOSPITAL   (Japan)

^c JAPANESE RED CROSS MEDICAL CENTER   (Japan)

Author keywords

Chromosome recombination; Human narcolepsy; Recombination breakpoint; Susceptibility region

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HLA ANTIGEN; HLA B ANTIGEN; HLA DR ANTIGEN;

ARTICLE; CENTROMERE; CHROMOSOME 6; CLINICAL ARTICLE; DNA POLYMORPHISM; FEMALE; GENE MAPPING; GENETIC PREDISPOSITION; GENETIC RECOMBINATION; HAPLOTYPE; HLA SYSTEM; HUMAN; JAPAN; MALE; NARCOLEPSY; PRIORITY JOURNAL; TELOMERE;

FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA ANTIGENS; HLA-B ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; MICROSATELLITE REPEATS; NARCOLEPSY; PEDIGREE; POLYMORPHISM, GENETIC; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; RECOMBINATION, GENETIC; TELOMERE; THIOLESTER HYDROLASES;

EID: 0034433373     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510000245     Document Type: Article

References (25)

1. Triplet repeat polymorphism within the NOTCH4 gene located near the junction of the HLA class II and class III regions in narcolepsy
2. Discrimination of human HLA-DRB1 alleles by PCR-SSCP (single-strand conformation polymorphism) method
3. HLA class II alleles in Ainu living in Hidaka district, Hokkaido, Northern Japan
4. Electrophoretically detectable polymorphism of the promoter region of the HLA-linked HSP-70-1 gene
5. Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus
6. Characterization of recombination in the HLA class II region
7. TAP2 gene polymorphism segregates with DR-DQ in DR/DP recombinant siblings
8. A highly polymorphic microsatellite marker in the human MHC class III region, close to the BAT2 gene
9. Genetic aspects of narcolepsy
10. HLA antigens in Japanese patients with narcolepsy: All the patients were DR2 positive
11. Genetic markers in narcolepsy
12. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
13. Recombination rates across the HLA complex: Use of microsatellites as a rapid screen for recombinant chromosomes
14. Genetics of narcolepsy and other sleep disorders
15. Genetic linkage of autosomal recessive canine narcolepsy with a μ immunoglobulin heavy-chain switch-like segment
16. DQCAR microsatellite polymorphisms in three selected HLA class II-associated diseases
17. Extensive HLA class II studies in 58 non-DRB1*15(DR2) narcoleptic patients with cataplexy
18. Mutations in the palmitoyl-protein thioesterase gene (PPT; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits
19. Direct sequencing of complement C4B5 and C4B2 alleles carried by characteristic MHC haplotypes
20. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
21. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
22. Complete sequence and gene map of a human major histocompatibility complex
23. Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis
24. Allelic polymorphism of two multifunctional regions in the central human MHC: Tenascin X, XB-S and YB, and their duplicated fragments XA and YA