Effect of F209S mutation of Escherichia coli AroG on resistance to phenylalanine feedback inhibition

Acta Biochimica et Biophysica Sinica

Volumn 32, Issue 5, 2000, Pages 441-444

  Jiang, Pei Hong ^a   Shi, Mi ^a   Qian, Zhi Kang ^a   Li, Ning Jun ^a   Huang, Wei Da ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Arog gene; Phenylalanine analogues; Point mutation; Resistance

Indexed keywords

EID: 0034414534     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

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2. Pittard J, Gibson F. In: Horecker B L, Stadtman E R eds. Current Topics in Cellular Regulation, New York: Academic Press, 1970, 2: 29-63
3. Brown K D, Somerville R L. Repression of aromatic amino acid biosynthesis in E.coli K-12. J Bacterial, 1971, 108: 386-399
4. Kikuchi Y, Tsujimoto K, Kurahashi O. Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli. Appl Environ Microbiol, 1996, 63: 761-762
5. Ger Y M, Chen S L, Chiang H J, Shiuan D. A single Ser-180 mutation desensitizes feedback inhibition of the phenylalaninesensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase in Escherichia coli. J Biochem , 1994, 116: 986-990
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7. Jiang P H, Liu A M, Ge H P, Zhang Y Y, Fan C S, Huang W D. Cloning and Expression of aroG gene of E. coli and its co-expression with pheA and tyrB genes. Acta Biochimica et Biophysica Sinica, 1998, 30(6): 593-596
8. Ray J M, Yanofsky C, Bauerle R. Mutational analysis of the catalytic and feedback sites of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Escherichia coli. J Bacterial, 1988, 170: 5500-5506
9. Weaver L M, Herrmann K M. Cloning of an aroF allele encoding a tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. J Bacterial, 1990, 172; 6581-6584