Selective formation of pyrrolo[3,2-d]pyrimidines from methyl[(N-benzoyl-S-methylisothiocarbamoyl)amino]-1H-pyrrole-2-carboxylate

Organic Process Research and Development

Volumn 4, Issue 2, 2000, Pages 129-130

  Pathak, Ved P ^a,b  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034395157     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op9901902     Document Type: Article

References (8)

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2. Giblett, E. R.; Ammann, A. J.; Wara, D. W.; Sandman, R.; Diamond, L. K. Lancet 1975, 1, 1011.
3. Montgomery, J. A.; Niwas, S.; Rose, J. D.; Secrist, J. A., III; Babu, Y. S.; Bugg, C. E.; Erion, M. D.; Guida, W. C.; Ealick, S. E. J. Med. Chem. 1993, 36, 55.
4. Secrist, J. A., III; Niwas, S.; Rose, J. D.; Babu, Y. S.; Bugg, C. E.; Erion, M. D.; Guida, W. C.; Ealick, S. E.; Montgomery, J. A. J. Med. Chem. 1993, 36, 1847.
5. Erion, M. D.; Niwas, S.; Rose, J. D.; Ananthan, S.; Allen, M.; Secrist, J. A., III; Babu, Y. S.; Bugg, C. E.; Guida, W. C.; Ealick, S. E.; Montgomery, J. A. J. Med. Chem. 1993, 36, 3771.
6. Lim, M. I.; Ren, W. Y.; Otter, B. A.; Klein, R. S. J. Org. Chem. 1983, 48, 780.
7. + + H) m/z 255.
8. 15N shift of an amino group is pH dependent, and ammonium appears at δ 42.5 (p 174).