Chemical Debridement of Pressure Ulcers: A Prospective, Randomized, Comparative Trial of Collagenase and Papain/Urea Formulations

Wounds

Volumn 12, Issue 2, 2000, Pages 15-25

  Alvarez, Oscar M ^a,b   Fernandez Obregon, Adolfo ^b   Rogers, Roisin S ^a,c   Bergamo, Louisa ^d   Masso, John ^d   Black, Marion ^e  

^a University Wound Care Centers   (United States)

^b Hudson Dermatology and Skin Cancer Center   (United States)

^c VISITING NURSE SERVICE OF NEW YORK   (United States)

^d Harborage Health Care Center   (United States)

^e Hamilton Park Health Care Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034384812     PISSN: 10447946     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Clark RAF. Cutaneous tissue repair: Basic biologic considerations. J Am Acad Dermatol 1985;13:701-25.
2. Rodeheaver G, Baharestani MM, Brabec ME, et al. Wound healing and wound management: Focus on debridement. Adv Wound Care 1994;7:22.
3. Hellgren L, Vincent J. Debridement: An essential step in wound healing. In: Westerhoff W (ed). Leg Ulcers Diagnosis and Treatment. Amsterdam: Elsevier Science, 1993:305-12.
4. Cohen IK. How do methods and timing of debridement affect the quality of repair? J Trauma 1984;24:S25.
5. Haury B, Rodeheaver G, Vensko J, Edgerton MT, Edlich RF. Debridement: An essential component of traumatic woundcare. Am J Surg 1978;135:238.
6. Fowler E, van Rijswijk L. Using wound debridement to help achieve the goals of care. Ost/Wound Mgt 1995;41:23S.
7. Berger MM. Enzyme debriding preparations. Ost/Wound Mgt 1992;38(8):26.
8. Alvarez OM. Pressure ulcers: Critical consideration in prevention and management. Clinical Materials 1991;8:209.
9. Kennedy KL, Tritch DL. Debridement. In: Krasner D, Kane D. (eds.) Chronic Wound Care, Second Edition. Wayne, PA: Health Management Publications, Inc., 1997:227-34.
10. Wiseman DM, Rovee DT, Alvarez OM. Wound dressings: Design and use. In: Cohen K, Diegelmann R, Lindbladt WJ (eds). Biochemical and Clinical Aspects of Wound Healing. Philadelphia, PA: WB Saunders, 1992:562-80.
11. Westerhof W. Future prospects of proteolytic enzymes and wound healing. In: Westerhoff W, Vanscheidt W (eds.) Protelytic Enzymes and Wound Healing. New York, NY: Springer-Verlag GmbH & Co., 1994:99-102.
12. Levenson SM, Gruber DK, Gruber C, Lent R, Seifter E. Chemical debridement of burns: Mercaptans. J Trauma 1981;21:632-44.
13. Burke JF, Golden T. A clinical evaluation of enzymatic debridement with papain/urea-chlorophillin ointment. Am J Surg 1958;95:828-42.
14. Levenson SM. Debriding agents. J Trauma 1979;19(S11):928-30.
15. Falabella A. Debridement of wounds. WOUNDS 1998;10(Suppl C):1C-9C.
16. Rao DB, Sane PG, Geogiev EL. Collagenase in the treatment of dermal and decubitus ulcers. J Am Ger Soc 1975;23:22-30.
17. Varma AO, Bugatch E. Debridement of dermal ulcers with collagenase Surg Gyn & Obs 1973;136:281-2.
18. Boxer AM, Gottesman N, Bernstein H, Mandl I. Debridement of dermal ulcers and decubiti with collagenase. Geriatrics 1969;24:75-86.
19. Lee LK, Ambrus JL. Collagenase therapy for decubitus ulcers. Geriatrics 1975;30:91-8.
20. Brown-Etris M, Punthello M, Shields D, Bateman D, et al. A comparison clinical study to evaluate the efficacy of 80% hypertonic wound gel dressing vs. collagenase ointment for the debridement of nonviable tissue in dermal ulcers. Abstract presented at the 11th Annual Symposium on Advanced Wound Care and Medical Research Forum on Wound Repair in Miami, FL, April 18-22, 1998.
21. Westerhof W, Jansen FC, deWit FS. Controlled double blind trial of fibrinolysin-deoxyribonuclease (Elase) solution in patients with chronic leg ulcers who are treated before autologous skin grafting. J Am Acad Dermatol 1987;17:32-8.
22. Silverstein P, Ruzicka FJ, Helmkamp GM Jr, Lincoln RA Jr, Mason AD Jr. In vitro evaluations of enzymatic debridemet of burn eschar. Surgery 1973;73(1):15-22.
23. Hebda PA, Flynn KJ, Dohar JE. Evaluation of efficacy of enzymatic debriding agents for removal of necrotic tissue and promotion of healing in porcine skin wounds. WOUNDS 1998;10(3):83-96.
24. Carter CH. Chronic ulcers: Treatment with papain/urea-chlorophyllin ointment. M Times 1958;86:1382.
25. Miller JM, Godfrey GC, Ginsberg M, Papastrat CJ. Clinical experience with Panafil. Postgrad Med 1957;22:609.
26. Miller JM. The interaction of papain/urea and water soluble chlorophyll in a proteolytic ointment for infected wounds. Surgery 1958;43:939.
27. Ehrenkranz NJ, Alfonso B, Nerenberg D. Irrigation-aspiration for culturing draining decubitus ulcers: Correlation of bacteriologic findings with a clinical inflammatory index. J Clin Microbiol 1990;28:2389-93.
28. Gilchrist JE, Campbell JE, Donnelly CB, et al. Spiral plate method for bacterial determination. Appl Envron Microbiol 1973;23:244-52.
29. Snedecor GW, Cochran WG. Statistical Methods, Sixth Edition. Ames, IA: The Iowa State University Press, 1974;91-119.
30. Zar JH. Biostatistical Analysis, Second Edition. Engelwood Cliffs, NJ: Prentice Hall Press, 1984.
31. Bergstrom N, Allman RM, Alvarez OM, Bennett MA, Carlson CE, et al. Clinical Practice Guideline Number 15: Treatment of Pressure Ulcers. Rockville, MD: US Department of Health and Human Services. Agency for Health Care Policy and Research; 1994. AHCPR Publication No. 95-0652.
32. Sinclair RD, Ryan TJ. Types of chronic wounds: Indications for enzymatic debridement. In: Westerhof W, Vanscheidt W (eds). Proteolytic Enzymes and Wound Healing. New York, NY: Springer-Verlag GmbH & Co., 1994:7-20.
33. Hobson D, White E, Anderson L, Lira L. Development and use of a quantitative method to evaluate the action of enzymatic wound debriding agents in vitro. WOUNDS 1998;10(4):105-10.
34. Hobson D, Lira L, Nijeha F. Evaluation of the effects of formulation factors on the action of wound debriding agents in vitro. Presented at the 30th Annual Conference of the Wound Ostomy and Continence Nursing Society in Salt Lake City, UT, June 13-17, 1998.