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As a leucocyte starts to crawl, part of its fluid cytoplasm turns rigid in a kind of sol-gel transition. The neutrophil extends a flat protrusion (leading lamella) that attaches to the underlying substrate, primarily through the action of membrane-adhesion proteins. The adhesion with the substrate provides a traction force that enables the cell to pull itself forward. The molecular motors provide a driving force to the actin filament that pushes the cell forward.
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15
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0002355708
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Ph.D. thesis, Thèse de doctorat de l'Université Grenoble I, Grenoble
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I. Cantat. Ph.D. thesis, Thèse de doctorat de l'Université Grenoble I, Grenoble, 1999.
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Bruinsma, R.1
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20
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0002347353
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note
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The reason for locality is the following. For a true surface in 3D any motion on some scale R induces a perturbation at least on that scale that couples different points on the surface. For a 1D object in 3D circulation of the liquid can wander around the line (or polymer-like geometry) without needing to affect distant points, leading thereby to local dynamics.
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