Double-blinded cross-over study on the efficacy of pentoxifylline for canine atopy

Veterinary Dermatology

Volumn 11, Issue 4, 2000, Pages 255-260

  Marsella, Rosanna ^a,b   Nicklin, Constance F ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b Scott)   (United States)

Author keywords

Canine atopy; Cytokines; Interleukin 6; Pentoxifylline; Tumour necrosis factor

Indexed keywords

ACARI; ASTIGMATA; CANIS FAMILIARIS; PYROGLYPHIDAE;

EID: 0034366129     PISSN: 09594493     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3164.2000.00196.x     Document Type: Article

References (31)

1. DeBoer, D.J. Advances in allergic disease. In: Advances in Veterinary Dermatology, Vol. 3; (eds Kwochka, K.K., Willemse, T., Tscharner, C.) Oxford, UK: Butterworth Heinemann, 1998: 147-76.
2. Cooper, K.D. Atopic dermatitis: recent trends in pathogenesis and therapy. Journal of Investigative Dermatology 1994; 102: 128-37.
3. Galli, S.J., Gordon, J.R., Wershil, B.K. Cytokine production by mast cells and basophils. Current Opinion in Immunology 1991; 3: 865-72.
4. Gordon, J.R., Galli, S.J. Mast cells are source of both preformed and inducible TNF-α. Nature 1990; 346: 274-6.
5. Reshef, A., Kagey-Sobotka, A., Adkinson, N.F., Lichtenstein, L.M., Norman, P.S. The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). Journal of Allergy and Clinical Immunology 1989; 84 (5 Part 1): 678-87.
6. Yokoyama, A., Kohno, N., Fujino, S. et al. Circulating IL-6 in patients with bronchial asthma. American Journal of Respiratory Critical Care and Medicine 1995; 151(5): 1354-8.
7. Lee, C.E., Neuland, M.E., Teaford, H.G. Interleukin 6 is released in the cutaneous response to antigen challenge in atopic individuals. Journal of Allergy and Clinical Immunology 1992; 89: 1010-21.
8. Gosset, P., Tsicopoulos, A., Wallaert, B., Joseph, M., Capron, A., Tonnel, A.B. Tumor necrosis factor alpha and IL-6 production by human mononuclear phagocytes from allergic asthmatic after IgE dependent stimulation. American Review of Respiratory Disease 1992; 146(3): 768-74.
9. Yamada, N., Wakugawa, M., Kuwata, S., Yoshida, T., Nakagawa, H. Chronologic analysis of in situ cytokine expression in mite allergen-induced dermatitis in atopic subjects. Journal of Allergy and Clinical Immunology 1995; 96: 1069-75.
10. Vercelli, D., Jabara, H.H., Arari, K., Yokota, T., Geha, R.S. Endogenous IL-6 plays an obligatory role in IL-4 dependent human IgE synthesis. European Journal of Immunology, 1989; 19: 1419-24.
11. Mandi, Y., Farkas, G., Ocsovsky, I., Nagy, Z. Inhibition of TNF-α production and ICAM-1 expression by pentoxifylline: beneficial effects in sepsis syndrome. Respiratory Experimental Medicine 1995; 195(5): 297-307.
12. Neuner, P., Klosner, G., Schauer, E. et al. Pentoxifylline in vivo down-regulates the release of IL-1β, IL-6, IL-8 and TNF-α by human peripheral blood mononuclear cells. Immunology 1994; 83(2): 262-7.
13. Xu, J.C., Guo, X.J., Mao, B.L. Effects of pentoxifylline on leukocyte in the lung of dogs with fat tissue extract induced respiratory distress. Chinese Journal of Internal Medicine 1994; 33(4): 248-50.
14. Marsella, R., Kunkle, G.A., Lewis, D.T. Pentoxifylline inhibits contact hypersensitivity reactions to plants of the Commelinceae family in dogs. Veterinary Dermatology 1997; 8 (2): 121-6.
15. Hargis, A.M., Mundell, A.C. Familial canine dermatomyositis. Compendium of Continuing Education 1992; 14: 855-7.
16. Bailly, S., Fay, M., Gourgerot-Pocidalo, M.A. Effects of antibiotics on production of cytokines by human monocytes. Pathologie Biologie 1993; 41 (8 Part 2): 838-44.
17. Friccius, H., Ophla, H., Adobzadeh, M., Siegels-Hubenthal, P., Schenk, A., Pawelec, G. The effects of antifungal azoles itraconazole, fluconazole, ketoconazole and miconazole on cytokine gene expression in human lymphoid cell. International Journal of Immunopharmacology 1992; 14 (5): 791-9.
18. Samlaska, C.P., Winfield, E.A. Pentoxifylline. Journal of the American Academy of Dermatology 1994; 30: 603-21.
19. 14C) an Ratten, Hunde und Menshen. Arzneimittel Forschung-Drug Research 1972; 22 (11): 1933-7.
20. Kurzman, I.D., Shi, F., MacEwen, E.G. In vivo and in vitro production of TNF induced by muramyl peptides and LPS. Veterinary Immunology and Immunopathology 1993; 38 (1-2): 45-56.
21. Shi, F., Kurzman, I.D., MacEwen, E.G. In vivo and in vitro production of IL-6 induced by muramyl peptides and LPS in normal dogs. Cancer and Biotherapy 1995; 10 (4): 317-25.
22. Sullivan, G.W., Carper, H.T., Novick, W.J., Mandell, G.L. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline. Infection and Immunology 1988; 56 (7): 1722-9.
23. Funk, J.O., Ernst, M., Schonharting, M.M., Zabel, P. Pentoxifylline exerts synergistic effects in combination with dexamethasone or cyclosporin A. International Journal of Pharmacology 1995; 17 (12): 1007-16.
24. Rieneck, K., Diamant, M., Haahr, P.M., Schonhareting, M., Bendtzen, K. In vitro immunomodulatory effects of pentoxifylline. Immunology Letters 1993; 37: 131-8.
25. Benbernou, N., Esnault, S., Potron, G., Guenounou, M. Regulatory effects of pentoxifylline on T helper cell-derived cytokine production in human blood cells. Journal of Cardiovascular Pharmacology 1995; 25 (Suppl. 2): S75-9.
26. Beerman, B., Ings, R., Mansby, J., Chamberlain, J., McDonald, A. Kinetics of intravenous and oral pentoxifylline in healthy subjects. Clinical Pharmacology and Therapeutics 1985; 37: 25-8.
27. Smith, R.V., Waller, E.S., Doluisio, J.T. et al. Pharmacokinetics of orally administered pentoxifylline in humans. Journal of Pharmaceutical Sciences 1986; 75 (1): 47-52.
28. Ward, A., Clissold, S. Pentoxifylline: a review of its pharmacodynamic and pharmacokinetic properties, and its efficacy. Drugs 1987; 34: 50-97.
29. McMillan, J.C., Heskel, N.S., Hanifin, J.M. Cyclic AMP-phosphodiesterase activity and histamine release in cord blood leukocyte preparations. Acta Dermato-Venereologica 1985; 114: 24-32.
30. Sawai, T., Ikai, K., Uehara, M. Cyclic adenosine monophosphate phosphodiesterase activity in peripheral blood mononuclear leukocytes from patients with atopic dermatitis: correlation with respiratory atopy. British Journal of Dermatology 1998; 138(5): 846-8.
31. Hirshman, C.A., Leu, D.B., Austin, D.R., Chan, S.C., Veith, L., Hanifin, J.M. Elevated mononuclear leukocyte phosphodiesterase in allergic dogs with and without airway hyperresponsiveness. Journal of Allergy and Clinical Immunology 1987; 79 (1): 46-53.