Diastereoselective pinacol coupling reaction of aliphatic and aromatic aldehydes promoted by low valent titanium iodide in situ formed by titanium(IV) iodide and copper

Chemistry Letters

Volumn , Issue 7, 2000, Pages 838-839

  Mukaiyama, Teruaki ^a   Yoshimura, Naritoshi ^a   Igarashi, Koji ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034339646     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2000.838     Document Type: Article

References (17)

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12. Copper powder was purchased from Soekawa Chemical Co., Ltd. and used as received. Other metals were dried under vacuum at 100 °C.
13. 2 suspended dark brown solution was cooled to 0 °C and a solution of 3-phenylpropionaldehyde (0.5 mmol) in dichloromethane (1.5 ml) was added. The reaction mixture was stirred for 6 hours, and then the work up was done as shown in Ref. 3. The crude product was purified by TLC to afford the desired pinacol and co-product (80% and 11%, respectively).
14. T. Hirao, M. Asahara, Y. Muguruma, and A. Ogawa J. Org. Chem., 63, 2812 (1998).
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