Hypoxanthine-guanine phosphoribosyltransferase reporter gene mutation for analysis of in vivo clonal amplification in patients with HTLV type 1-associated myelopathy/tropical spastic paraparesis

AIDS Research and Human Retroviruses

Volumn 16, Issue 16, 2000, Pages 1747-1752

  Albertini, Richard J ^a,b   Ardell, Stephanie K ^a,b   Judice, Steven A ^a,b   Jacobson, Steven ^a,b   Allegretta, Mark ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b BioMosaics Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CELL DIVISION; CLINICAL ARTICLE; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS INFECTION; LEUKEMOGENESIS; LYMPHOCYTE CLONE; MUTAGENESIS; MUTATION RATE; NEWBORN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; VIRUS CARRIER;

CLONE CELLS; GENES, REPORTER; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTATION; PARAPARESIS, TROPICAL SPASTIC; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; VIRUS INTEGRATION;

EID: 0034332202     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220050193254     Document Type: Article

References (7)

1. Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1 associated myelopathy (HAM-TSP)
2. Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome
3. T cells responsive to myelin basic protein in patients with multiple sclerosis
4. HPRT: Gene structure, expression, and mutation
5. In vivo somatic mutations in humans: Measurement and analysis
6. T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood
7. The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans