Analysis of CREB mutants in Tax complex formation and trans-activation

AIDS Research and Human Retroviruses

Volumn 16, Issue 16, 2000, Pages 1597-1601

  Mick, J E ^a   Colgin, M A ^a   Brauweiler, A ^a   Nyborg, J K ^a  

^a Immunology and Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; TAX PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS DNA;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DELETION MUTANT; GENE EXPRESSION; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; VIRUS GENE;

CREB-BINDING PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE DELETION; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; NUCLEAR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034332168     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220050193010     Document Type: Article

References (18)

1. HTLV-1-associated diseases
2. Human retroviruses: Their role in cancer
3. CREB-mediated transcriptional control
4. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
5. Transcriptional regulation by cyclic AMP
6. Human T-cell leukemia virus type I Tax requires direct access to DNA for recuitment of CREB binding protein to the viral promoter
7. Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking
8. The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove
9. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
10. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation
11. An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300
12. Molecular interactions between the coactivator CBP and the human T-cell leukemia virus Tax protein
13. In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax
14. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB
15. The coactivator CBP stimulates human T-cell lymphotropic virus type I Tax transactivation in vitro
16. Identification of p40(x)-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat
17. PCAF interacts with Tax and stimulates Tax transactivation in a histone acetyltransferase-independent manner
18. p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 tax in a multi-histone acetyltransferase/activator-enhancer complex