Effect of dietary supplements containing antioxidants on attenuation of muscle damage in exercising sled dogs

American Journal of Veterinary Research

Volumn 61, Issue 11, 2000, Pages 1438-1445

  Piercy, Richard J ^a   Hinchcliff, Kenneth W ^a   DiSilvestro, Robert A ^a   Reinhart, Gregory A ^b   Baskin, Carole R ^a   Hayek, Michael G ^b   Burr, John R ^b   Swenson, Richard A ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b Lams Company   (United States)

^c Lightning Bolt Express Kennels   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CHOLESTEROL; CREATINE KINASE; RETINOL; TRIACYLGLYCEROL; URIC ACID;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOG; DRUG EFFECT; ENZYMOLOGY; HEALTH STATUS; MUSCLE; PATHOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BODY WEIGHT; CHOLESTEROL; CREATINE KINASE; DIETARY SUPPLEMENTS; DOGS; HEALTH STATUS; MUSCLES; PHYSICAL CONDITIONING, ANIMAL; TRIGLYCERIDES; URIC ACID; VITAMIN A; VITAMIN E;

EID: 0034330590     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2000.61.1438     Document Type: Article

References (49)

1. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hcmocuprein). J Biol Chem 1969;244:6049-6055.
2. Sen CK. Oxidants and antioxidants in exercise. J Appl Physiol 1995;79:675-686.
3. Davies KJ, Quintanilha AT, Brooks GA, et al. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun 1982;107:1198-1205.
4. Hinchcliff KW, Reinhart GA, Burr JR, et al. Metabolizable energy intake and sustained energy expenditure of Alaskan sled dogs during heavy exertion in the cold. Am J Vet Res 1997;58:1457-1462.
5. Mataix J, Quiles JL, Huertas JR, et al. Tissue specific interactions of exercise, dietary fatty acids, and vitamin E in lipid peroxidation. Free Radic Biol Med 1998;24:511-521.
6. Dekkers JC, van Doornen LJ, Kemper HC. The role of antioxidant vitamins and enzymes in ihe prevention of exercise-induced muscle damage. Sports Med 1996,21:213-238.
7. Amelink GJ, van der Wal WA, Wokke JH, et al. Exercise-induced muscle damage in the rat: the effect of vitamin E deficiency. Pflugers Arch 1991;419:304-309.
8. Frankiewicz-Jozko A, Faff J, Sieradzan-Gabelska B. Changes in concentrations of tissue free radical marker and serum creatine kinase during the post-exercise period in rats. Eur J Appl Physiol 1996;74:470-474.
9. Aktas M, Auguste D, Lefebvre HP, et al. Creatine kinase in the dog: a review. Vet Res Commun 1993;17:353-369.
10. Maughan RJ, Donnelly AE, Gleeson M, et al. Delayed-onset muscle damage and lipid peroxidation in man after a downhill run. Muscle Nerve 1989;12:332-336.
11. Sumida S, Tanaka K, Kitao H, et al. Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation. Int J Biochem Cell Biol 1989;21:835-838.
12. Hinchcliff KW, Reinhart GA, DiSilvestro RA, et al. Oxidant stress in Alaskan sled dogs subjected to repetitive endurance exercise. Am J Vet Res 2000;61:512-517.
13. Sumida S, Doi T, Sakurai M, et al. Effect of a single bout of exercise and beta-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans. Free Radic Res 1997;27: 607-618.
14. Alessio HM, Goldfarb AH, Cao G. Exercise-induced oxidative stress before and after vitamin C supplementation. Int J Sport Nutr 1997;7:1-9.
15. Goldfarb AH, McIntosh MK, Boyer BT, et al. Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats. J Appl Physiol 1994;76:1630-1635.
16. Meydani M, Evans WJ, Handelman G, et al. Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am J Physiol 1993;264:992-998.
17. Gohil K, Packer L, de Lumen B, et al. Vitamin E deficiency and vitamin C supplements: exercise and mitochondrial oxidation. J Appl Physiol 1986;60:1986-1991.
18. Kanter MM, Nolte LA, Holloszy JO. Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. J Appl Physiol 1993;74:965-969.
19. Bowry VW, ingold KU, Stocker R. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a prooxidant. Biochem J 1992;288:341-344.
20. Witt EH, Reznick AZ, Viguie CA, et al. Exercise, oxidative damage and effects of antioxidant manipulation. J Nutr 1992;122: 766-773.
21. KaikkonenJ, Kosonen L, Nyyssonen K, et al. Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. Free Radic Res 1998;29:85-92.
22. Hinchcliff KW, Shaw LC, Vukich NS, et al. Effect of distance traveled and speed of racing on body weight and serum enzyme activity of sled dogs competing in a long-distance race. J Am Vet Med Assoc 1998;213:639-644.
23. Chew BP, Wong MW, Wong TS. Effects of lutein from marigold extract on immunity and growth of mammary tumors in mice. Anticancer Res 1996;16:3689-3694.
24. Park JS, Chew BP, Wong TS. Dietary lutein absorption from marigold extract is rapid in BALB/c mice. J Nutr 1998;128: 1802-1806.
25. Roe JH, Kuether CA. The determination of ascorbic acid in whole blood and urine through the 2,4-dinitrophenylhydrazine derivative of dehydroascorbic acid. J Biol Chem 1943;147: 399-407.
26. Ji LL. Exercise and oxidative stress: role of the cellular antioxidant systems. Exert Sport Sci Rev 1995;23:135-166.
27. Pillai SR, Traber MG, Steiss JE, et al. Alpha-tocopherol concentrations of the nervous system and selected tissues of adult dogs fed three levels of vitamin E. Lipids 1993;28:1101-1105.
28. Uotila JT, Kirkkola AL, Rorarius M, et al. The total peroxyl radical-trapping ability of plasma and cerebrospmal fluid in normal and preeclamptic parturients. Free Radic Biol Med 1994;16:581-590.
29. Rasanen LA, Wiitanen PA, Lilius EM, et al. Accumulation of uric acid in plasma after repeated bouts of exercise in the horse. Comp Biochem Physiol B Biochem Mol Biol 1996;114:139-144.
30. Vasankari TJ, Kujala UM, Vasankari TM, et al. Effects of acute prolonged exercise on-serum and LDL oxidation and antioxidant defences. Free Radic Biol Med 1997;22:509-513.
31. Cao G, Prior RL. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem 1998;44:1309-1315.
32. Reynolds AJ, Fuhrer L, Dunlap HL, et al. Lipid metabolite responses to diet and training in sled dogs. J Nutr 1994;124: 2754S-2759S.
33. Horwitt MK, Harvey CC, Dahm CH, Jr, et al. Relationship between tocophcrol and serum lipid levels for determination of nutritional adequacy. Ann N Y Acad Sci 1972;203:223-236.
34. Thurnham DI, Davies JA, Crump BJ, et al. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann Clin Biochem 1986;23:514-520.
35. Craig AM, Blythe LL, Lassen ED, et al. Variations of serum vitamin E, cholesterol, and total serum lipid concentrations in horses during a 72-hour period. Am J Vet Res 1989;50:1527-1531.
36. Roneus BO, Hakkaramen RV, Lindholm CA, et al. Vitamin E requirements of adult Standardbred horses evaluated by tissue depletion and repletion. Equine Vet J 1986;18:50-58.
37. Rokitzki L, Logemann E, Sagredos AN, et al. Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta Physiol Scand 1994;151:149-158.
38. Ames BN, Cathcart R, Schwiers E, et al. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981; 78:6858-6862.
39. Sevanian A, Davies K, Hochstein P. Conservation of vitamin C by uric acid in the blood. J Free Radical Biol Med 1985;1:117-124.
40. Sjodin B, Hellsten Westing Y, Apple FS. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med 1990;10:236-254.
41. Issekutz B, Miller H, Paul P, et al. Source of fat oxidation in exercising dogs. Am J Physiol 1964;207:583-589.
42. Terjung RL, Budohoski L, Nazar K, et al. Chylomicron triglyceride metabolism in resting and exercising fed dogs. J Appl Physiol 1982;52:815-820.
43. Teare JA, Krook L, Kallfelz FA, et al. Ascorbic acid deficiency and hypertrophic osteodystrophy in the dog: a rebuttal. Cornell Vet 1979;69:384-401.
44. Loscher W, Jaeschkc G, Keller H. Pharmacokinetics of ascorbic acid in horses. Equine Vet J 1984;16:59-65.
45. Baker H, DeAngelis B, Baker E, et al. Human plasma patterns during 14 days ingestion of vitamin E, beta-carotene, ascorbic acid, and their various combinations. J Am Coll Nutr 1996;15:159-163.
46. Anonymous. Vitamin A. In: National Research Council (US) Subcommittee on Vitamin Tolerance. Vitamin tolerance of animals. Washington, DC: National Academy Press. 1987;3-10.
47. Warren JA, Jenkins RR, Packer L, et al. Elevated muscle vitamin E does not attenuate eccentric exercise-induced muscle injury. J Appl Phvsiol 1992;72:2168-2175.
48. Helgheim I, Hetland O, Nilsson S, et al. The effects of vitamin E on serum enzyme levels following heavy exercise. Eur J Appl Physiol 1979;40:283-289.
49. Siciliano PD, Parker AL, Lawrence LM. Effect of dietary vitamin E supplementation on the integrity of skeletal muscle in exercised horses. J Anim Sci 1997;75:1553-1560.