Enzyme biosensor for studying therapeutics of Alzheimer's disease

Biosensors and Bioelectronics

Volumn 15, Issue 9-10, 2000, Pages 541-547

  Lenigk, Ralf ^a   Lam, Edmund ^a   Lai, Ada ^a   Wang, Hong ^a   Han, Yifan ^a   Carlier, Paul ^a   Renneberg, Reinhard ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Biosensor

Indexed keywords

BIOELECTRIC POTENTIALS; DISEASES; ENZYME INHIBITION; NEUROPHYSIOLOGY;

ACETYLCHOLINESTERASE INHIBITORS; ALZHEIMER'S DISEASE;

ENZYME SENSORS;

4 AMINOQUINALDINE; ACETYLCHOLINESTERASE; CHOLINE OXIDASE; CHOLINESTERASE INHIBITOR; HEPTYLENE LINKED BIS 9 AMINO 1,2,3,4 TETRAHYDROACRIDINE; OXIDOREDUCTASE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMPEROMETRY; ARTICLE; BIOSENSOR; CHOLINESTERASE INHIBITION; DRUG SCREENING; ENZYME ELECTRODE; ENZYME IMMOBILIZATION; IC 50; INTERMETHOD COMPARISON; PHOTOMETRY;

ACETYLCHOLINESTERASE; ALCOHOL OXIDOREDUCTASES; ALZHEIMER DISEASE; ANIMALS; BIOSENSING TECHNIQUES; CATTLE; CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; ENZYMES, IMMOBILIZED; HUMANS; RATS;

EID: 0034325114     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0956-5663(00)00078-6     Document Type: Article

References (12)

1. Cholinesterase inhibitors do more than inhibit cholinesterase
2. Determination of organophosphorus and carbamate insecticides by flow injection analysis
3. Biosensor for detection of organophosphate and carbarnate pesticides
4. Abnormalities of acetylcholinesterase in Alzheimer's disease with special reference to effect of acetylcholinestrase inhibitor
5. 50 values represent?
6. Dissection of the human acetylcholinesterase active center determinants of substrate specificity: Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket
7. Synthesis of alkylene linked Bis-THA and alkylene linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase
8. Determination of anticholinesterase pesticides in real samples using a disposable biosensor
9. Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase
10. Cognitive enhancers in theory and practice: Studies of the cholinergic hypothesis of cognitive deficits in Alzheimer disease
11. A new approach for discriminative detection of organophosphate neurotoxins in the presence of other cholinesterase inhibitors
12. Acetylcholinesterase inhibition by tacrine analogues