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Volumn 17, Issue 5, 2000, Pages 1043-1051
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UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells.
a
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Author keywords
[No Author keywords available]
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Indexed keywords
7 HYDROXYSTAUROSPORINE;
7-HYDROXYSTAUROSPORINE;
ALKALOID;
ANTINEOPLASTIC AGENT;
CAMPTOTHECIN;
DNA;
DNA TOPOISOMERASE (ATP HYDROLYSING);
DRUG DERIVATIVE;
ENZYME INHIBITOR;
PROTEIN KINASE C;
PROTEIN P53;
STAUROSPORINE;
TUMOR PROTEIN;
ADENOCARCINOMA;
ARTICLE;
BREAST;
BREAST TUMOR;
CELL CULTURE;
CELL CYCLE;
COMPARATIVE STUDY;
CYTOLOGY;
DNA DAMAGE;
DNA REPAIR;
DNA REPLICATION;
DRUG ANTAGONISM;
DRUG EFFECT;
DRUG POTENTIATION;
DRUG SCREENING;
EPITHELIUM CELL;
FEMALE;
GENE EXPRESSION REGULATION;
GENETICS;
HUMAN;
PATHOLOGY;
PHYSIOLOGY;
TUMOR SUPPRESSOR GENE;
ADENOCARCINOMA;
ALKALOIDS;
ANTINEOPLASTIC AGENTS;
BREAST;
BREAST NEOPLASMS;
CAMPTOTHECIN;
CELL CYCLE;
DNA DAMAGE;
DNA REPAIR;
DNA REPLICATION;
DNA TOPOISOMERASES, TYPE II;
DNA, NEOPLASM;
DRUG SCREENING ASSAYS, ANTITUMOR;
DRUG SYNERGISM;
ENZYME INHIBITORS;
EPITHELIAL CELLS;
FEMALE;
GENE EXPRESSION REGULATION, NEOPLASTIC;
GENES, P53;
HUMANS;
NEOPLASM PROTEINS;
PROTEIN KINASE C;
STAUROSPORINE;
TUMOR CELLS, CULTURED;
TUMOR SUPPRESSOR PROTEIN P53;
MLCS;
MLOWN;
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EID: 0034324572
PISSN: 10196439
EISSN: None
Source Type: Journal
DOI: 10.3892/ijo.17.5.1043 Document Type: Article |
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Times cited : (20)
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References (0)
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