Endocytosis of Clostridium botulinum Type B Neurotoxin into Rat Brain Synaptosomes

Journal of Veterinary Medical Science

Volumn 62, Issue 11, 2000, Pages 1133-1138

  Kohda, Tomoko ^a,b   Kamata, Yoichi ^a   Kozaki, Shunji ^a  

^a Osaka Prefecture University   (Japan)

^b Nara Livestock Hygiene Service Center   (Japan)

Author keywords

Clostridium botulinum; Endocytosis; Neurotoxin; Synaptosome; VAMP

Indexed keywords

CLOSTRIDIUM BOTULINUM;

BOTULINUM TOXIN; MEMBRANE PROTEIN; NERVE PROTEIN; NEUROTOXIN; NORADRENALIN; SYNAPTOBREVIN;

ANIMAL; ARTICLE; BRAIN; DRUG EFFECT; ENDOCYTOSIS; METABOLISM; RAT; SYNAPTOSOME;

ANIMALS; BOTULINUM TOXINS; BRAIN; ENDOCYTOSIS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEUROTOXINS; NOREPINEPHRINE; R-SNARE PROTEINS; RATS; SYNAPTOSOMES;

EID: 0034320606     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.62.1133     Document Type: Article

References (32)

1. Ashton, A. C. and Dolly, J. O. 1988. Characterzation of the inhibitory action of botulinum neurotoxin type A on the release of several transmitters from rat cerebrocortical synaptosomes. J. Neurochem. 50: 1808-1816.
2. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
3. Brose, N., Petrenko, A. G., Südhof, T. C. and Jahn, R. 1992. Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science 256: 1021-1025.
4. Burnette, W. M. 1981. "Western Blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112: 195-203.
5. Donovan, J. J. and Middlebrook, J. L. 1986. Ion-conducting channels produced by botulinum toxin in planar lipid membranes. Biochemistry 25: 2872-2876.
6. 2+ sensor for transmitter release at a central synapse. Cell 79: 717-727.
7. Grest, J. E. 1999. SNAREs and SNARE regulators in membrane fusion and exocytosis. Cell. Mol. Life Sci. 55: 707-734.
8. Hayashi, T., MaMahon, H., Yamasaki, S., Binz, T., Hata, Y., Südhof, T. C. and Niemann, H. 1994. Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. EMBO J. 13: 5051-5061.
9. Hoch, D. H., Romcro-Mira, M., Ehrlich, B. E., Finkelstein, A., DasGupta, B. R. and Simpson, L. L. 1985. Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes. Proc. Natl. Acad. Sci. U.S.A. 82: 1692-1696.
10. Huttner, W. B., Schiebler, W., Greengard, P. and De Camilli, P. 1983. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J. Cell Biol. 96: 1374-1388.
11. Kamata, Y. and Kozaki, S. 1994. The light chain of botulinum neurotoxin forms channels in a lipid membrane. Biochem. Biophys. Res. Commun. 205: 751-757.
12. Kozaki, S., Kamata, Y., Watarai, S., Nishiki, T. and Mochida, S. 1998. Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins. Microb. Pathog. 25: 91-99.
13. Kozaki, S., Miyazaki, S. and Sakaguchi, G. 1977. Development of antitoxin with each of two complementary fragments of Clostridium botulinum type B derivative toxin. Infect. Immun. 18: 761-766.
14. Kozaki, S., Ogasawara, J., Shimote, Y., Kamata, Y. and Sakaguchi, G. 1987. Antigenic structure of Clostridium botulinum type B neurotoxin and its interaction with gangliosides, cerebroside, and free fatty acid. Infect. Immun. 55: 3051-3056.
15. Kozaki, S., Sakaguchi, S. and Sakaguchi, G. 1974. Purification and some properties of progenitor toxins of Clostridium botulinum type B. Infect. Immun. 10: 750-756.
16. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227: 680-685.
17. 2+-dependent manner. Trends Neurosci. 18: 177-183.
18. Montal, M. S., Blewitt, R., Tomich, J. M. and Montal, M. 1992. Identification of an ion channel-forming motif in the primary structure of tetanus and botulinum neurotoxins. FEBS Lett. 313: 12-18.
19. Montecucco, C. and Schiavo, G. 1994. Mechanism of action of tetanus and botulinum neurotoxins. Mol. Microbiol. 13: 1-8.
20. Niemann, H., Blasi, J. and Jahn, R. 1994. Clostridial neurotoxins: new tools for dissecting exocytosis. Trends Cell Biol. 4: 179-185.
21. Nishiki, T., Kamata, Y., Nemoto, Y., Omori, A., Ito, T., Takahashi, M. and Kozaki, S. 1994. Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes. J. Biol. Chem. 269: 10498-10503.
22. Nishiki, T., Tokuyama, Y., Kamata, Y., Nemoto, Y., Yoshida, A., Sato, K., Sekiguchi, M., Takahashi, M. and Kozaki, S. 1996. The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/ GD1a. FEBS Lett. 378: 253-257.
23. Perin, M. S., Brose, N., Jahn, R. and Südhof, T. C. 1991. Domain structure of synaptotagmin (p65). J. Biol. Chem. 266: 623-629.
24. Sakaguchi, G. 1983. Clostridium botulinum toxins. Pharmacol. Ther. 19: 165-194.
25. Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., Polverino de Laureto, P., DasGupta, B. R. and Montecucco, C. 1992. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature (Lond.) 359: 832-834.
26. Schiavo, G., Osborne, S. L. and Sgouros, J. G. 1998. Synaptotagmins: more isoforms than functions? Biochem. Biophys. Res. Commun. 248: 1-8.
27. Shoji-Kasai, Y., Yoshida, A., Sato, K., Hoshino, T., Ogura, A., Kondo, S., Fujimoto, Y., Kuwahara, R., Kato, R. and Takahashi, M. 1992. Neurotransmitter release from synaptotagmin-deficient clonal variants of PC 12 cells. Science 256: 1820-1823.
28. Simpson, L. L. 1986. Molecular pharmacology of botulinum toxin and tetanus toxin. Ann. Rev. Pharmacol. Toxicol. 26: 427-453.
29. Sugiyama, H. 1980. Clostridium botulinum neurotoxin. Mirobiol. Rev. 44: 419-448.
30. Walch-Solimena, C., Blasi, J., Edelmann, L., Chapman, E. R., Fisher von Mollard, G. and Jahn, R. 1995. The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling. J. Cell Biol. 128: 637-645.
31. Whittaker, V. P. 1959. The isolation and characterization of acetylcholine containing particles from brain. Biochem. J. 72: 694-706.
32. Zhang, J. Z., Davletov, B. A., Südhof, T. C. and Anderson, R. G. W. 1994. Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling. Cell 78: 751-760.