Preoperative UFT/ leucovorin and radiation therapy in rectal cancer

ONCOLOGY

Volumn 14, Issue 10 SUPPL. 9, 2000, Pages 56-58

  Hoff, Paulo M ^a   Saad, Everardo D ^a   Janjan, Nora ^a   Skibber, John ^b   Pazdur, Richard ^c  

^a Department of Gastrointestinal Medical Oncology and Digestive Diseases ^*

^b UNIVERSITY OF TEXAS   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 UFT PROTOCOL; 1-UFT PROTOCOL; ANTINEOPLASTIC AGENT; FOLINIC ACID; TEGAFUR; URACIL;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG COMBINATION; FEMALE; HUMAN; MALE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; RECTUM TUMOR; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; RECTAL NEOPLASMS; TEGAFUR; TREATMENT OUTCOME; URACIL;

EID: 0034304706     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Greenlee RT, Murray T, Bolden S, et al: Cancer statistics, 2000. CA Cancer J Clin 50:7-31, 2000.
2. Douglas HO Jr, Moertel CG, Mayer RJ, et al: Survival after postoperative combination treatment of rectal cancer. N Engl J Med 315:1294-1295, 1986.
3. Krook JE, Moertel CG, Gunderson LL, et al: Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324:709-715, 19991.
4. O'Connell MJ, Martenson JA, Wieand HS, et al: Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331:502-507, 1994.
5. Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rates. J Clin Oncol 10:896-903, 1992.
6. Tepper JE, O'Connell MJ, Petroni GR, et al: Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: Initial results of Intergroup 0114. J Clin Oncol 15:2030-2039, 1997.
7. Minsky BD: Adjuvant postoperative combined-modality therapy for rectal cancer. Oncology (Huntington) 13(suppl 3):132-135, 1999.
8. Liu G, Franssen E, Fitch MI, Warner E: Patient preference for oral vs intravenous palliative chemotherapy. J Clin Oncol 15:110-115, 1997.
9. Hoff PM, Pazdur R, Benner SE, et al: UFT and leucovorin: A review of its clinical development and therapeutic potential in the oral treatment of cancer. Anticancer Drugs 9:479-490, 1998.
10. Hirata K, Sasaki K, Yamamitsu S, Shiraska T: A comparison of 5-fluorouracil concentration of 5-fluorouracil drip infusion vs oral UFT in plasma of same patients [in Japanese]. Jpn J Cancer Chemother 20:1409-1411, 1993.
11. Ho DH, Pazdur R, Covington W, et al: Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous infusion and oral uracil plus N1-(2′-tetrahydrofuryl)-5-fluorouracil. Clin Cancer Res 4:2085-2088, 1998.
12. Okabe H, Toko T, Saito H, et al: Augmentation of the chemotherapeutic effectiveness of UFT, a combination of tegafur [1-(2-tetrahydrofuryl)-5-fluorouracil] with uracil, by oral 1-leucovorin. Anticancer Res 17:157-164, 1997.
13. Pazdur R, Douillard J-Y, Skillings JR, et al: Multicenter phase III study of 5-fluorouracil (5-FU) UFT in combination with leucovorin (LV) in patients with metastatic colorectal cancer (abstract 1009). Proc Am Soc Clin Oncol 18:263, 1999.
14. Carmichael J, Popiela T, Radstone D, et al: Randomized comparative study of ORZEL (oral uracil/tegafur [UFT] plus leucovorin [LV]) vs parenteral 5-fluorouracil (5-FU) in patients with metastatic colorectal cancer (abstract 1015). Proc Am Soc Clin Oncol 18:264a, 1999.
15. Wagman R, Minsky BD, Cohen AM, et al: Sphincter preservation in rectal cancer with preoperative radiation therapy and coloanal anastomosis: Long- term follow-up. Int J Radiat Oncol Biol Phys 42:51-57, 1998.
16. Rich TA: Infusional chemoradiation for operable rectal cancer: Post-, pre-, or nonoperative management? Oncology (Huntington) 11:295-300, 1997.
17. Minsky BD: Sphincter preservation in rectal cancer. Preoperative radiation therapy followed by low anterior resection with coloanal anastomosis. Semin Radial Oncol 8:30-35, 1998.
18. Pazdur R, Lassere Y, Rhodes V, et al: Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol 12:2296-2300, 1994.