Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells

Journal of Immunology

Volumn 165, Issue 7, 2000, Pages 4007-4014

  Enomoto, A ^a   Murakami, M ^a   Valentin, E ^a   Lambeau, G ^a   Gelb, M H ^a   Kudo, I ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BETA N ACETYLHEXOSAMINIDASE; HEPARIN; HISTAMINE; IMMUNOGLOBULIN E; LYSOPHOSPHOLIPID; PHOSPHOLIPASE A2; PROSTAGLANDIN D2;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXOCYTOSIS; GENETIC TRANSFECTION; MAST CELL DEGRANULATION; MASTOCYTOMA; MEDIATOR RELEASE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETORY GRANULE; SITE DIRECTED MUTAGENESIS; SOUTHERN BLOTTING;

EID: 0034292359     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.7.4007     Document Type: Article

References (49)

1. 2 in mouse bone marrow-derived mast cells
2. 2 generation via prostaglandin endoperoxide synthase-2
3. 2
4. 2: Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes
5. 2
6. 2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways
7. 2 with the glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan in the cyclooxygenase-2-mediated delayed prostanoid-biosynthetic pathway
8. 2s in regulating arachidonic acid release and prostaglandin generation: Implications of cyclooxygenase-2 induction and phospholipid scramblase-mediated cellular membrane perturbation
9. 2 generation in rat 3Y1 fibroblasts
10. 2s
11. 2 is phosphorylated and activated by MAP kinase
12. 2 in allergic response and parturition
13. 2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells
14. 2 gene family in mammals
15. 2: Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes
16. 2s
17. 2s
18. 2 that mediates prostaglandin production in mast cells
19. 2 generation in mouse bone marrow-derived mast cells
20. 2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by interaction with fibroblasts and mediated by a mechanism independent of their enzymatic functions
21. 2s related but not identical to type IIA isozyme in cultured mast cells
22. 2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion
23. 2 from activated mast cells and its possible involvement in the regulation of the degranulation process
24. 2 inhibitors suppresses lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells
25. 2
26. 2 enzymes
27. Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free system
28. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
29. 2
30. Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5
31. 2 associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation
32. 2 enzymes have different intracellular locations in mouse bone marrow-derived mast cells
33. min-induced intestinal neoplasia
34. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14
35. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin-3 and c-kit ligand
36. 2
37. 2
38. 2 are natural ligands of the mouse 180-kDa M-type receptor
39. 2
40. 2 in the secretory granule
41. 2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen
42. Lipids in biological membrane fusion
43. 2
44. 2: Interfacial parameters, substrate specificities, and competitive inhibitors
45. 2 has a dramatically increased ability to hydrolyze phosphatidylcholine vesicles and cell membranes
46. 2 for phosphatidic acid
47. 2 on cell membranes: Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme
48. 2
49. 2-dependent induction of cyclooxygenase-2 in macrophages