Effect of PKC on glucose-mediated insulin secretion in HIT-T15

Journal of the Pancreas

Volumn 1, Issue 3, 2000, Pages 49-57

  Akiyoshi, Hiroko ^a   Nakaya, Yutaka ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Potassium channels; Protein kinase C; Staurosporine

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; GLIBENCLAMIDE; GLUCOSE; INSULIN; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM ION; PROTEIN KINASE C; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL LINE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; INSULIN RELEASE; MEMBRANE CURRENT; NONHUMAN; PATCH CLAMP; REGULATORY MECHANISM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; ANIMAL; CELL CULTURE; DOSE RESPONSE; ENZYMOLOGY; HAMSTER; PANCREAS ISLET; PHYSIOLOGY; SECRETION;

ANIMALS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; PROTEIN KINASE C; TUMOR CELLS, CULTURED;

EID: 0034285513     PISSN: 15908577     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Ashcroft FM, Harrison DE, Ashcroft SJH. Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Nature 1984; 312:446-8.
2. + channels in pancreatic B-cells. Nature 1984; 311:271-3.
3. +-channels in pancreatic beta-cells are regulated by intracellular ATP. Pflugers Arch 1985; 405:305-9.
4. 2+ concentration in pancreatic beta-cells. J Biol Chem 1987; 262:5448-54.
5. + channel in insulin-secreting cells. J Biol Chem 1987; 262:15840-4.
6. Henquin JC, Charles S, Nenquin M, Mathot F, Tamagawa T. Diazoxide and D 600 inhibition of insulin release. Diabetes 1982; 31:776-83.
7. + channels in mouse B cells. J Clin Invest 1992; 89:1288-95.
8. + channels in mouse B cells. J Clin Invest 1993; 91:871-80.
9. + channel-independent glucose action in rat pancreatic b-cell. Am J Physiol 1994; 266:C622-7.
10. Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312:315-21.
11. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 1983; 306:67-9.
12. Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 1984; 308:693-8.
13. Tanigawa K, Kuzuya H, Imura H, Taniguchi H, Baba S, Takai Y, et al. Calcium-activated, phospholipid-dependent protein kinase in rat pancreas islets of langerhans. FEBS Lett 1982; 138:183-6.
14. 2+-phospholipid-dependent and cyclic AMP-dependent protein kinases in mouse pancreatic islets. Biochem J 1984; 221:247-53.
15. 2+- phospholipid-dependent protein kinase in rat islets and hamster beta-cells. Biochem J 1984; 219:547-51.
16. Hutton JC, Peshavaria M, Brocklehurst KW. Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma. Biochem J 1984; 224:483-90. [85096790]
17. 2+-dependent translocation of protein kinase C and glucose-induced insulin release. J Biol Chem. 1996; 271:18154-60. [96279367]
18. Nishizuka Y. Studies and perspectives of protein kinase C. Science 1986; 233:305-12. [86261771]
19. + currents in a neuronal cell. Nature 1986; 323:333-5. [87014781]
20. + channels in cultured pancreatic islet cells. J Membr Biol 1985; 88:165-72.
21. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391:85-100.
22. Nishizuka Y. The family of protein kinase C for signal transduction. J Am Med Assoc 1989; 262:1826-33.
23. Malaisse WJ, Sener A, Herchuelz A, Carpinelli AR, Poloczek P, Winand J, et al. Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets. Cancer Res 1980; 40:3827-31.
24. Malaisse WJ, Lebrun P, Herchuelz A, Sener A, Malaisselagae F. Synergistic effect of a tumor-promoting phorbol ester and a hypoglycemic sulfonylurea upon insulin release. Endocrinology 1983; 113:1870-7.
25. Hii CST, Jones PM, Persaud SJ, Howell SL. A re-assessment of the role of protein kinase C in glucose-stimulated insulin secretion. Biochem J 1987; 246:489-93.
26. 2+ and protein kinase C in acetylcholine-induced insulin release in the clonal beta-cell line, HIT-T15. Biochem J 1990; 267:227-32. [90226320]
27. + channels. EMBO J 1988; 7:2443-9. [89052657]
28. Eddlestone GT, Ribalet B, Ciani S. Comparative study of K channel behavior in beta cell lines with different secretory responses to glucose. J Membr Biol 1989; 109:123-34