Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia

Human Molecular Genetics

Volumn 9, Issue 14, 2000, Pages 2067-2074

  Geurts, Jan M W ^a   Janssen, Rob G J H ^a   Van Greevenbroek, Marleen M J ^a   Van Der Kallen, Carla J H ^a   Cantor, Rita M ^b   Bu, Xiang Dong ^c   Aouizerat, Bradley E ^b   Allayee, Hooman ^b   Rotter, Jerome I ^c   De Bruin, Tjerk W A ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Steven Spielberg Pediatric Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; APOLIPOPROTEIN B; ARGININE; CYTOSINE; METHIONINE; NUCLEOTIDE; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; FAMILIAL HYPERLIPEMIA; FAMILY STUDY; FEMALE; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC LINKAGE; GENOME; GENOTYPE; HAPLOTYPE; HEART INFARCTION; HOMOZYGOSITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTIGENE FAMILY; NETHERLANDS; NUCLEOTIDE REPEAT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0034284684     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.14.2067     Document Type: Article

References (42)

1. Hyperlipidemia in coronary heart disease. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
2. Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia
3. LDL physical and chemical properties in familial combined hyperlipidemia
4. Segregation analysis of plasma apolipoprotein B levels in familial combined hyperlipidemia
5. The influence of age and relative weight on the presentation of familial combined hyperlipidemia in childhood
6. Complex segregation analysis of hyperlipidemia in a Seattle sample
7. Bimodality of plasma apolipoprotein B levels in familial combined hyperlipidemia
8. Complex segregation analysis provides evidence for a major gene acting on serum triglyceride levels in 55 British families with familial combined hyperlipidemia
9. Genetic predictors of FCHL in four large pedigrees. Influence of APOB level major locus predicted genotype and LDL subclass phenotype
10. Linkage of familial combined hyperlipidemia to chromosome 1q21-q23
11. A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11
12. Mapping a gene for combined hyperlipidemia in a mutant mouse strain
13. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
14. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
15. Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance
16. Tumor necrosis factor stimulates hepatic lipid synthesis and secretion
17. Evidence for two classes of cytokines that stimulate hepatic lipogenesis: Relationships among tumor necrosis factor, interleukin-1 and interferon-alpha
18. Tumor necrosis factor-alpha acutely inhibits insulin signalling in human adipocytes
19. Effects of tumor necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism in of newly-differentiated human fat cells in cell culture
20. Differential regulation of lipoprotein lipase in the macrophage J774.2 cell line by cytokines
21. Dexamethasone differently modulates TNF-alpha- and IL-1 beta-induced transcription of the hepatic Mn-superoxide dismutase gene
22. Endotoxin and TNF lead to reduced plasma LCAT activity and decreased hepatic LCAT mRNA levels in Syrian hamsters
23. Linkage of a candidate gene locus to familial combined hyperlipidemia-lecithin:Cholesterol acyltransferase on 16q
24. Two TNF receptors
25. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation and death
26. The tumor necrosis factor ligand and receptor families
27. Isolation and characterization of a tumor necrosis factor binding protein from urine
28. Soluble forms of tumor necrosis factors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor
29. Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization
30. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors
31. Physical mapping and genomic structure of the human TNFR2 gene
32. Soluble receptors for tumor necrosis factor-α (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia
33. A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families
34. Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus
35. Population choice in mapping genes for complex diseases
36. Functional analysis of tumor necrosis factor (TNF) receptors in TNF alpha-mediated insulin resistance in genetic obesity
37. A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality
38. Apolipoprotein AI/CIII/AIV gene cluster in familial combined hyperlipidemia: Effects on LDL-cholesterol and apolipoproteins B and C-II
39. Complex genetic contribution of the apoAI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes
40. Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome: Correlation with plasma creatine values
41. Optimal temperature selection for mutation detection by denaturing high performance liquid chromatography and comparison to SSCP and heteroduplex analysis