Cellular and molecular mechanism for kilham rat virus-induced autoimmune diabetes in DR-BB rats

Journal of Immunology

Volumn 165, Issue 5, 2000, Pages 2866-2876

  Chung, Y H ^a   Hee Sook Jun, ^a   Son, M ^a   Bao, M ^a   Hak Yeon Bae, ^a   Kang, Y ^a   Yoon, J W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; EPITOPE;

ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; DIABETES MELLITUS; EFFECTOR CELL; IMMUNE RESPONSE; LATENT RAT PARVOVIRUS; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; VIRUS;

EID: 0034284233     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.5.2866     Document Type: Article

References (55)

1. Immunopathogenesis of diabetes mellitus
2. Insulin-dependent diabetes mellitus
3. Spontaneous diabetes mellitus: Reversal and prevention in the BB/W rat with antiserum to rat lymphocytes
4. Spontaneous diabetes in rats: Destruction of islets is prevented by immunological tolerance
5. Spleen cell transfusion in the Bio-Breeding/Worcester rat: Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells
6. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat
7. Passive transfer of diabetes in the BB/W rat
8. Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats
9. Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages
10. Studies on autoimmunity for the initiation of β cell destruction. V. Decrease of macrophage-dependent T-lymphocytes and NK cytotoxicity in silica-treated DP-BB rats
11. Induction of type I diabetes by Kilham's rat virus in diabetes-resistant BB/Wor Rats
12. Kilham rat virus triggers T-cell-dependent autoimmune diabetes in multiple strains of rat
13. Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes-resistant Bio-Breeding rats
14. Parvovirus replication
15. Isolation and structural characterization of monomeric and dimeric forms of replicative intermediates of Kilham rat virus DNA
16. Requirement of cellular synthesis for Kilham rat virus replication
17. Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats
18. A new look at viruses in type I diabetes
19. General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes
20. Cellular and humoral immune response to rubella virus structural proteins E-1, E2, and C
21. Expression of proteins in mammalian cells using vaccinia viral vectors
22. Prevention of autoimmune type I diabetes in BioBreeding (BB) rats by a newly established, autoreactive T cell line from acutely diabetic BB rats
23. + suppressor T cells in superantigen-treated non-obese diabetic mice
24. Identification of DNA-replicating lymphocytes subsets using a new method to label the bromo-deoxyuridine incorporated into the DNA
25. Turnover of naive- and memory-phenotype T cells
26. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
27. A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats
28. Target organ-specific up-regulation of MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis
29. Intra-cerebral cytokine mRNA expression during fatal and nonfatal αvirus encephalitis suggests a predominant type 2 T cell response
30. Cytokine gene expression in islets thyroid of BB rats: IFN-γ and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats
31. Construction of a genetic switch for inducible trans-activation of gene expression in eucaryotic cells
32. Characterization of the trans-activation-responsive element of the parvovirus H-1 P38 promoter
33. Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant vires expressing LCMV-WE nucleo-protein or glycoprotein
34. A recombinant vector derived from the host-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus
35. Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety
36. Natural killer cell depletion and diabetes mellitus in the BB/Wor rat
37. + T cells and their roles in the induction and prevention of autoimmunity
38. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: Therapeutic intervention by immunostimulation?
39. + T cells in the pathogenesis of organ-specific autoimmune disease
40. The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
41. + T cells induce wasting disease with multiple organs pathology: Prevention by the OX-22(low) subset
42. + T cell subset that inhibits this autoimmune potential
43. + T cells
44. + T cells
45. - T helper cells
46. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
47. + T cells
48. + suppressor T cell, NY 4.2, in the prevention of autoimmune IDDM in NOD mice
49. Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 but not in Th2 clones
50. The injection of deaggre gated T globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes
51. Aqueous antigens induce in vivo tolerance selectively in IL-2 and IFN-γ-producing (Th1) cells
52. Differential ability of T cell subsets to undergo activation-induced cell death
53. Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid fas/fasL-mediated apoptosis
54. Thymic epithelial defects and predisposition to autoimmune disease in BB rats
55. Adoptive transfer of autoimmune diabetes and thyroidiris to athymic rats