The determination of a chlorinated benzofuran pharmaceutical intermediate by HPLC-MS with on-line derivatization

Journal of Pharmaceutical and Biomedical Analysis

Volumn 23, Issue 4, 2000, Pages 705-713

  Novak, T J ^a   Yuan, Huimin ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

2 chloromethylbenzofuran; HPLC MS; On line derivatization; Protease inhibitor

Indexed keywords

2 CHLOROMETHYLBENZOFURAN; BENZOFURAN DERIVATIVE; N (HYDROXYINDANYL)PHENYLMETHYLHYDROXY 5 [1 (4 (2 BENZO[B]FURANYLMETHYL) N' 9 TERT BUTYL CARBOXAMIDO)PIPERAZINYL]PENTANEAMIDE; PROTEINASE INHIBITOR; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; DERIVATIZATION; DRUG DETERMINATION; DRUG PURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

BENZOFURANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV PROTEASE INHIBITORS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; MASS SPECTROMETRY; ONLINE SYSTEMS; TEMPERATURE;

EID: 0034284136     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(00)00351-4     Document Type: Article

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