Overexpression of cathepsin B and urokinase plasminogen activator is associated with increased risk of recurrence and metastasis in patients with chondrosarcoma

Cancer

Volumn 89, Issue 5, 2000, Pages 995-1003

  Häckel, Carsten G ^a   Krueger, Sabine ^a   Grote, Hans Jürgen ^a   Oshiro, Yumi ^b   Hodges, Sherie ^b   Johnston, Dennis A ^b   Johnson, Mark E ^b   Roessner, Albert ^a   Ayala, Alberto G ^b   Czerniak, Bogdan ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cellular proteases; Chondrosarcoma; Immunohistochemistry; Prognosis

Indexed keywords

CATHEPSIN B; CATHEPSIN L; COLLAGENASE; GELATINASE A; GELATINASE B; PROTEINASE; UROKINASE;

ADULT; ARTICLE; CANCER GRADING; CANCER RECURRENCE; CANCER RISK; CANCER SURVIVAL; CHONDROSARCOMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR GROWTH;

ADULT; BONE NEOPLASMS; CATHEPSIN B; CATHEPSINS; CHONDROSARCOMA; COHORT STUDIES; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 1; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RECURRENCE; RISK FACTORS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; URINARY PLASMINOGEN ACTIVATOR;

EID: 0034283778     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20000901)89:5<995::AID-CNCR8>3.0.CO;2-8     Document Type: Article

References (40)

1. Cancer statistics 2000
2. Epidemiology of bone cancers
3. Prognostic factors in chondrosarcoma of bone: A clinicopathologic analysis with emphasis on histologic grading
4. Altered p53 is associated with aggressive behavior of chondrosarcoma: A long-term follow-up study
5. Chondrosarcoma of bone: The experience at the Istituto Orthopedico Rizzoli
6. The biology of human chondrosarcoma. I. Description of cases, grading, and biological analyses
7. Histological grading of chondrosarcoma
8. Chondrosarcoma: A clinicopathologic and statistical analysis
9. The diagnosis and grading of chondrosarcoma of bone: A combined cytologic and histologic approach
10. The role of proteolytic enzymes in cancer invasion and metastasis
11. Prognostic impact and clinical relevance of tumor-associated proteases in breast cancer
12. Degradation of cartilage matrix components by the cystein proteases, cathepsins B and L
13. Production of matrix-metalloproteinases and a metalloproteinase inhibitor by swarm rat chondrosarcoma
14. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3
15. Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas
16. Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcomas
17. Expression of plasminogen activators and plasminogen activator inhibitor I in dedifferentiated chondrosarcoma
18. Protease expression in dedifferentiated parosteal osteosarcoma. An immunomorphological study
19. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies
20. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 2 (72-kDa gelantinase/ type IV collagenase) using monoclonal antibodies
21. Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors
22. Inhibition of matrix metalloproteinase 9 activation by a specific monoclonal antibody
23. Cathepsin B, cathepsin H, cathepsin L
24. Proteases in the lysosome
25. Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues
26. Prognostic significance of cathepsins B and L in primary breast cancer
27. Cathepsin B expression and laminin degradation as factors influencing prognosis of surgically treated patients with lung adenocarcinoma
28. Plasminogen activator dependent pathway in the dissemination of human tumor ceils in the chick embryo
29. The plasminogen activator system in extracellular matrix degradation
30. Prognostic value of urokinase-type plasminogen activator in 671 primary breast cancer patients
31. Expression of urokinase-type plasminogen activator, stromelysin 1, stromelysin 3, and matrilysin genes in lung carcinomas
32. High level of urokinase-type plasminogen activator is a new prognostic marker in patients with gastric carcinoma
33. Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis
34. Tumor cell interactions with the extracellular matrix during invasion and metastasis
35. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer
36. Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer